Lactococcus lactis L1A-23 and Reduced Severity of Allergic Rhinitis Symptoms

• Probiotics combined with prebiotics alleviated seasonal allergic rhinitis by altering the composition and metabolic function of intestinal microbiota: a prospective, randomized, double-blind, placebo-controlled clinical trial.

  • 2024-11-01
  • RCT · n = 106
  • Frontiers in immunology 15
  • • Yangfan Hou
    • Dan Wang
    • Shuru Zhou
    • Caifang Huo
    • Haijuan Chen
    • Fangxia Li
    • Minjuan Ding
    • Hongxin Li
    • Hongyan Zhao
    • Jin He
    • Hongju Da
    • Yu Ma
    • Zhihui Qiang
    • Xiushan Chen
    • Cairong Bai
    • Jing Cui
    • Na Gao
    • Yun Liu

  • PubMed: 39555052
  • DOI: 10.3389/fimmu.2024.1439830

  3 Insights on

  • Reduced Severity of Allergic Rhinitis Symptoms

  • High evidence
  • Large Human Trial

  From baseline to day 91, mean difference between groups (MDBG) in the reduction of TNSS was -1.1 (-2.2, -0.1) (P = 0.04); ... Probiotics combined with prebiotics administered for 90 days significantly attenuated the symptoms of seasonal AR patients

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

• Lacticaseibacillus rhamnosus GG in a chewable colonizes the nose and facilitates local immune benefits in allergic rhinoconjunctivitis patients.

  • 2025-10-07
  • RCT
  • Microbiology spectrum 13(10)
  • • Ilke De Boeck
    • Irina Spacova
    • Eline Cauwenberghs
    • Tom Eilers
    • Thies Gehrmann
    • Karlien Van den Bossche
    • Katleen Martens
    • Sandra Condori-Catachura
    • Kato Michiels
    • Fien De Winter
    • Samir Kumar-Singh
    • Nicolas Bruffaerts
    • Ann Packeu
    • Peter W Hellings
    • Anneclaire Vroegop
    • Klara Van Gool
    • Olivier M Vanderveken
    • Sarah Lebeer

  • PubMed: 40891819
  • DOI: 10.1128/spectrum.00773-25

  3 Insights on

  • Reduced Severity of Allergic Rhinitis Symptoms

  • High evidence

  Control of self-reported AR symptoms via validated questionnaires under grass pollen exposure was observed after 2 weeks of probiotic administration and not upon placebo.

  Effect

  Beneficial

  Effect size

  Moderate