Effects of Lactococcus lactis from Cyprinus carpio L. as probiotics on growth performance, innate immune response and disease resistance against Aeromonas hydrophila.
- 2019-10
- Clinical Trial
- Fish & Shellfish Immunology 93
- Junchang Feng
- Xulu Chang
- Yuru Zhang
- Xiao Yan
- Jianxin Zhang
- G. Nie
- PubMed: 31302283
- DOI: 10.1016/j.fsi.2019.07.028
- Low evidence
- Animal Study
For the cytokines expression levels in serum, different expression patterns were also observed. Before the infection with Aeromonas hydrophila, L. lactis supplementation significant up-regulated protein levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-12) compared with negative (CK1) group, while these cytokines were significantly lower than those in positive (CK2) group after infection. However, whether infected or not, the expression of anti-inflammatory cytokines (IL-10, TGF-β) were significantly increased in L. lactis Q-8, L. lactis Q-9, and L. lactis Z-2 treatment groups.
- Effect
- Beneficial
- Effect size
- Large
- Significant
- Yes