Lactococcus lactis and Increased Systemic GABA Levels

• GABA-Producing Capabilities of Lactococcus lactis PL186 in Murine and Human.

  • 2026-03-20
  • Journal of microbiology and biotechnology 36
  • • Jennifer Jaemin Paek
    • Hyungwon Yang
    • Kyung Soo Paek
    • Yeonhee Lee

  • PubMed: 41866909
  • DOI: 10.4014/jmb.2512.12040

  2 Insights on

  • Increased Systemic GABA Levels

  • Low evidence

  In mice, this strain adheres to the intestinal mucosa, resulting in increased GABA levels in both serum and brain tissue. Additionally, L. lactis PL186 effectively colonizes the human gut and elevates GABA concentration in urine, highlighting its potential for systemic GABA enhancement.

  Effect

  Beneficial

  Effect size

  Moderate