Pediococcus acidilactici CECT9879 (pA1c) Counteracts the Effect of a High-Glucose Exposure in C. elegans by Affecting the Insulin Signaling Pathway (IIS)
- 2022-02-28
- Clinical Trial
- International Journal of Molecular Sciences 23(5)
- Deyan Yavorov-Dayliev
- F. Milagro
- J. Ayo
- M. Oneca
- P. Aranaz
- PubMed: 35269839
- DOI: 10.3390/ijms23052689
- Low evidence
- Animal Study
Gene expression analyses demonstrated that the probiotic metabolic syndrome-alleviating activities were mediated by modulation of the insulin/IGF-1 signaling pathway (IIS) through the reversion of the glucose-nuclear-localization of daf-16 and the overexpression of ins-6 and daf-16 mediators
- Effect
- Beneficial
- Effect size
- Large