Pediococcus acidilactici and Improved Intestinal Barrier Function

• Investigation of the Effects of Postbiotics Obtained from Pediococcus acidilactici on Specific Biomarker Expressions in Intestinal Tissue.

  • 2026-04-07
  • n = 78
  • Foods (Basel, Switzerland) 15(7)
  • • Ismail Demircioğlu
    • Muhammet Bahaeddin Dörtbudak
    • Funda Aksünger Karaavci
    • Mehmet Emin Aydemir
    • Muhammed Demircioğlu
    • Aydın Genç
    • Ayşegül Demircioğlu
    • Güven Güngör
    • Alessandro Di Cerbo

  • PubMed: 41976561
  • DOI: 10.3390/foods15071267

  2 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence

  immunohistochemical analysis revealed that the postbiotic increased the expression of CLDN3, OCLN, ZO1, AQP4, and AQP8, proteins involved in intestinal permeability and fluid transport, in a dose-dependent manner.

  Effect

  Beneficial

  Effect size

  Moderate

• Lactobacillus acidophilus combined with Pediococcus acidilactici ameliorates colitis.

  • 2026-03-04
  • Frontiers in microbiology 17
  • • Peilin Yu
    • Yuanming Jin
    • Da-Jeong Park
    • Mingzhu Wang
    • Chong-Su Cho
    • Chunri Yan
    • Fuliang Sun
    • Xin Jin
    • Keesun Yu
    • Young Jin Pyung
    • Cheol-Heui Yun
    • Lianhua Cui

  • PubMed: 41859447
  • DOI: 10.3389/fmicb.2026.1773197

  8 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence

  increased the mRNA expression levels of tight junction proteins

  Effect

  Beneficial

  Effect size

  Moderate

• Alginate alleviates hyperuricemia by modulating the Pediococcus acidilactici LW1-1-butyrate-NLRP3 inflammasome axis.

  • 2026-04
  • International journal of biological macromolecules 354
  • • Yukun Li
    • Rongshuang Han
    • Rong Wang
    • Xiaoyan Zhang
    • Mengchen Shan
    • Tianyu Fu
    • Yupeng Li
    • Xingsi Qi
    • Bin Cao
    • Yi Wang
    • Tao Mao
    • Zibin Tian

  • PubMed: 41819315
  • DOI: 10.1016/j.ijbiomac.2026.151318

  4 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence
  • Animal Study

  P. acidilactici LW1-1 enriched butyrate-producing bacteria and increased butyrate levels, thereby protecting against intestinal inflammation and barrier dysfunction... Both P. acidilactici LW1-1 and butyrate suppressed intestinal inflammation by inhibiting NLRP3 inflammasome activation and enhancing tight junction integrity.

  Effect

  Beneficial

  Effect size

  Moderate