Pediococcus pentosaceus KABP-041 and Reduced Crying Duration

• Infantile Colic Treated With Bifidobacterium longum CECT7894 and Pediococcus pentosaceus CECT8330: A Randomized, Double-Blind, Placebo-Controlled Trial

  • 2021-09-10
  • RCT · n = 112
  • Frontiers in Pediatrics 9
  • • Ke Chen
    • Changqi Liu
    • Hua Li
    • Yuehua Lei
    • Chenggui Zeng
    • Shuhong Xu
    • Jianqiu Li
    • F. Savino

  • PubMed: 34568236
  • DOI: 10.3389/fped.2021.635176

  2 Insights on

  • Reduced Crying Duration

  • High evidence

  Infants in the IG had significantly shorter crying time (p < 0.001) on day 7 [IG vs. PG, median (25-75th percentile): 38 (3.5-40.5) vs. 62 (40-108) min/day], day 14 [IG vs. PG: 20 (0-40) vs. 50 (30-75) min/day], and day 21 [IG vs. PG: 14 (0-33) vs. 40 (28-62) min/day].

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes