Propionibacterium freudenreichii MAK10P23F and Reduced Pro-inflammatory Cytokine Levels

• Probiotic Propionibacterium freudenreichii requires SlpB protein to mitigate mucositis induced by chemotherapy

  • 2019-12-31
  • Oncotarget 10(68)
  • • F. L. R. do Carmo
    • Houem Rabah
    • B. F. Cordeiro
    • S. H. da Silva
    • R. M. Pessoa
    • S. O. Fernandes
    • V. Cardoso
    • V. Gagnaire
    • M. Deplanche
    • Bruna Savassi
    • Alessandra Figueiroa
    • E. Oliveira
    • Caio Fonseca
    • Maria Izabel Alves Queiroz
    • N. M. Rodrigues
    • S. Sandes
    • Á. Nunes
    • Luísa Lemos
    • J. Alves
    • A. C. Faria
    • Ê. Ferreira
    • Y. Le Loir
    • G. Jan
    • V. Azevedo

  • PubMed: 31921383
  • DOI: 10.18632/oncotarget.27319

  4 Insights on

  • Reduced Pro-inflammatory Cytokine Levels

  • Low evidence

  In an in vitro assay, P. freudenreichii WT reduced expression of IL-8 (p<0.0001) and TNF-α (p<0.0001) cytokines in LPS-stimulated HT-29 cells.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes