Saccharomyces boulardii and Reduced Diarrhea Recurrence

• Randomized, direct comparison study of Saccharomyces boulardii CNCM I-745 versus multi-strained Bacillus clausii probiotics for the treatment of pediatric acute gastroenteritis

  • 2022-09-09
  • RCT · n = 317
  • Medicine 101(36)
  • • J. Altcheh
    • Mabel V. Carosella
    • A. Ceballos
    • Ulises D’Andrea
    • Sandra M. Jofre
    • Carolina R. Marotta
    • Domingo Mugeri
    • Liliana Sabbaj
    • A. Soto
    • C. Josse
    • F. Montestruc
    • L. Mcfarland

  • PubMed: 36086703
  • DOI: 10.1097/MD.0000000000030500

  7 Insights on

  • Reduced Diarrhea Recurrence

  • High evidence
  • Large Human Trial

  Secondary outcomes included frequency of loose stools/day, severity of diarrhea, number reporting no diarrhea at Day 6, time-to-first formed stool, recurrence of diarrhea by study end (Day 12) ... Both probiotics showed improvement in secondary outcomes

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

  Dose

  not stated