Saccharomyces boulardii and Reduced Immunogenicity After Oral Vaccination

• Design and immunogenicity of a recombinant Saccharomyces boulardii secreting the P2-VP8 subunit rotavirus vaccine.

  • 2026-02-02
  • Clinical Trial
  • Scientific reports 16(1)
  • • Ibrahim Farhani
    • Ahad Yamchi
    • Hadi Razavi Nikoo
    • Fatemeh T Shamsabadi
    • Shahriyar Abdoli
    • R Holland Cheng
    • Majid Shahbazi

  • PubMed: 41629582
  • DOI: 10.1038/s41598-026-37374-5

  2 Insights on

  • Reduced Immunogenicity After Oral Vaccination

  • High evidence
  • Rigorous Journal

  However, our in vivo results demonstrated poor immunogenicity following vaccination and can be improved in future studies.

  Effect

  Harmful

  Effect size

  Small