Saccharomyces boulardii and Reduced Virulence / Lower Risk of Fungemia

• ENA1 deficiency attenuates Saccharomyces 'boulardii' probiotic yeast virulence in immunosuppressed mouse fungaemia model.

  • 2026-03-06
  • Communications biology 9(1)
  • • Alexandra Imre
    • Renátó Kovács
    • Ágnes Jakab
    • Andrea Harmath
    • Bálint Németh
    • Fruzsina Nagy
    • Lajos Forgács
    • Dávid Balázsi
    • László Majoros
    • Zsigmond Benkő
    • Nathan Crook
    • István Pócsi
    • Walter P Pfliegler

  • PubMed: 41792460
  • DOI: 10.1038/s42003-026-09763-z

  1 Insight on

  • Reduced Virulence / Lower Risk of Fungemia

  • Low evidence

  Only ENA1 deletion diminished virulence in our mouse fungemia model... resulting in engineered strains with drastically reduced capability to cause bloodstream infections even in immunosuppressed hosts

  Effect

  Beneficial

  Effect size

  Moderate