Saccharomyces cerevisiae and Disrupted Bacterial Cell Membranes

• Potent Antimicrobial Activity of Aspergillus oryzae Fermentate Against Toxigenic Strains of Clostridioides difficile.

  • 2025-03-22
  • Antibiotics (Basel, Switzerland) 14(4)
  • • Ahmad Alshannaq
    • Morgan Henning
    • Jonah Dixon
    • Colleen Riley
    • Dasol Choi
    • Jae-Hyuk Yu
    • Nasia Safdar

  • PubMed: 40298462
  • DOI: 10.3390/antibiotics14040333

  2 Insights on

  • Disrupted Bacterial Cell Membranes

  • Low evidence

  Mechanistic studies using scanning electron microscopy (SEM) and flow cytometry revealed that the fungal extract induced severe membrane disruption, leading to intracellular leakage and complete lysis. Flow cytometry analysis confirmed membrane depolarization and permeability loss on C. difficile cells.

  Effect

  Beneficial

  Effect size

  Large