Saccharomyces cerevisiae and Reduced Angiotensin I-Converting Enzyme Activity

• Antihypertensive peptides from whey proteins fermented by lactic acid bacteria.

  • 2018-07-06
  • Food science and biotechnology 27(6)
  • • Eric Banan-Mwine Daliri
    • Byong H Lee
    • Byun-Jae Park
    • Se-Hun Kim
    • Deog-Hwan Oh

  • PubMed: 30483443
  • DOI: 10.1007/s10068-018-0423-0

  3 Insights on

  • Reduced Angiotensin I-Converting Enzyme Activity

  • Low evidence

  Their fermentates also displayed varying abilities to inhibit ACE in vitro. Seven fermentates showed strong ACE inhibitory abilities...

  Effect

  Beneficial

  Effect size

  Moderate

• Casein fermentate of Lactobacillus animalis DPC6134 contains a range of novel propeptide angiotensin-converting enzyme inhibitors.

  • 2007-07-15
  • n = 72
  • Applied and environmental microbiology 73(14)
  • • M Hayes
    • C Stanton
    • H Slattery
    • O O'Sullivan
    • C Hill
    • G F Fitzgerald
    • R P Ross

  • PubMed: 17483275
  • DOI: 10.1128/aem.00096-07

  2 Insights on

  • Reduced Angiotensin I-Converting Enzyme Activity

  • Low evidence
  • Rigorous Journal
  • Animal Study

  The crude 10-kDa L. animalis DPC6134 fermentate exhibited ACE-inhibitory activity of 85.51% (+/-15%) and had a 50% inhibitory concentration (IC50) of 0.8 mg protein/ml compared to captopril, which had an IC50 value of 0.005 mg/ml.

  Effect

  Beneficial

  Effect size

  Moderate