Streptococcus salivarius and Reduced Streptococcus pyogenes Colonization

• Description of the draft genome sequence of Streptococcus salivarius eK12, a derivative of the probiotic strain Streptococcus salivarius K12 with a modified plasmid.

  • 2025-07-08
  • Microbiology resource announcements 14(8)
  • • Francesco Di Pierro
    • Aswin Thacharodi
    • Muthiah Kumaraswami
    • Alexander Bertuccioli
    • Maria Laura Tanda
    • Nicola Zerbinati

  • PubMed: 40626761
  • DOI: 10.1128/mra.00355-25

  2 Insights on

  • Reduced Streptococcus pyogenes Colonization

  • Low evidence

  eK12 was engineered to enhance its probiotic properties against S. pyogenes (GAS) by modulating salivabactin production and interfering with a GAS quorum sensing pathway.

  Effect

  Beneficial

  Effect size

  Moderate