Description of the draft genome sequence of Streptococcus salivarius eK12, a derivative of the probiotic strain Streptococcus salivarius K12 with a modified plasmid.
- 2025-07-08
- Microbiology resource announcements 14(8)
- PubMed: 40626761
- DOI: 10.1128/mra.00355-25
Study Design
- Methods
- The draft genome of Streptococcus salivarius eK12, a derivative of the strain K12 with a modified plasmid (pRSSL1), is presented.
The draft genome of Streptococcus salivarius eK12, a derivative of the strain K12 with a modified plasmid (pRSSL1), is presented. eK12 was engineered to enhance its probiotic properties against S. pyogenes (GAS) by modulating salivabactin production and interfering with a GAS quorum sensing pathway.
Research Insights
| Supplement | Dose | Health Outcome | Effect Type | Effect Size | Source |
|---|---|---|---|---|---|
| Streptococcus salivarius | — | Reduced Streptococcus pyogenes Colonization | Beneficial | Moderate | View sourceeK12 was engineered to enhance its probiotic properties against S. pyogenes (GAS) by modulating salivabactin production and interfering with a GAS quorum sensing pathway. |
| Streptococcus salivarius K12 | — | Reduced Risk of S. pyogenes Infection | Beneficial | Moderate | View sourceeK12 was engineered to enhance its probiotic properties against S. pyogenes (GAS) by modulating salivabactin production and interfering with a GAS quorum sensing pathway. |