Research synthesisModerate evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful
Across all 3 studies, soy protein supplementation showed beneficial moderate-sized effects on reducing blood cholesterol. Two studies found moderate reductions (e.g., total cholesterol decrease of -20.55 mg/dL in CKD patients; mean difference -0.55 for cholesterol in T2DN patients), while one study found a small reduction (WMD = -0.11) in postmenopausal women. The evidence is based primarily on clinical populations with kidney disease or diabetes, and no specific dose range emerged from the available data.
- Studied populations: individuals with chronic kidney disease, patients with type 2 diabetic nephropathy, postmenopausal women
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Additionally, all studies were conducted in specific clinical populations (CKD, diabetic nephropathy, postmenopausal women); benefits may not generalize to healthy individuals.
Generated May 25, 2026