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Evidence-Based Supplement Research
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Soy Protein and Reduced LDL Cholesterol

Research synthesisLow evidenceMixed effect size3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported beneficial effects on LDL cholesterol reduction (one moderate, one small), while 1 found no effect. The evidence is preliminary and based on a small number of studies, with the only specific dose reported being 40 g/day. Median study duration (90 days) comes from a single trial.

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. The beneficial effects were observed in a systematic review of patients with type 2 diabetic nephropathy and a meta-analysis that may include other protein sources, while a direct RCT in a mixed population (40 g/day, 90 days) found no effect on LDL cholesterol. Effect sizes vary (moderate to small), and overall certainty is low.

Generated Jul 11, 2026
Doses used in studies
  • %/day: 35 (median 35, IQR 35–35) — 1 study
  • g/day: 40 (median 40, IQR 40–40) — 1 study
Time to effect
Median: 3 months · IQR 3 months–3 months · Range 3 months–3 months — Reported in 1 of 3 studies
3 of 3 papers
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