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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Soy Protein and Reduced Total Blood Cholesterol

Research synthesisModerate evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects on total blood cholesterol, with predominantly moderate effect sizes. The evidence is drawn from meta-analyses in clinical populations including chronic kidney disease, diabetic nephropathy, and postmenopausal women. Doses and study durations were inconsistently reported.

  • Studied populations: clinical populations (chronic kidney disease, type 2 diabetic nephropathy, postmenopausal women)

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Additionally, the evidence base is small (only 3 studies) — conclusions should be considered preliminary. Effect sizes ranged from small to moderate.

Generated May 18, 2026
Doses used in studies
  • %/day: 35 (median 35, IQR 35–35) — 1 study
3 of 3 papers
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