Understanding High Homocysteine Levels and Their Impact on Health Despite Normal B12
Explore the relationship between high homocysteine, normal B12 levels, and symptoms like memory loss and muscle pain. Learn how to discuss these concerns with your doctor and inquire about potential deficiencies or additional testing for comprehensive assessment.
B12 levels appear normal at 312, homocysteine is high at 18, biggest symptom is memory loss to the point where i can not function, that and muscle pain. Does this seem like a b12 deficiency? what should i say to my doctor, since my b12 itself is normal
High homocysteine levels with normal B12 levels can still be a concern and could be related to symptoms like memory loss and muscle pain. Elevated homocysteine is associated with an increased risk of cardiovascular issues and may also impact muscle strength1.
It's important to address these symptoms with your doctor, as they can evaluate if further testing is needed to rule out conditions such as folate or vitamin B6 deficiencies, which can also affect homocysteine levels. Additionally, even normal B12 levels may not rule out functional deficiencies or the need for other diagnostic approaches.
When discussing with your doctor, consider mentioning:
- Your Symptoms: Clearly describe the memory loss and muscle pain you're experiencing.
- Homocysteine Levels: Highlight the elevated homocysteine level you have.
- Functional Deficiency: Ask if a functional deficiency could still be present despite normal serum B12 levels.
- Additional Testing: Inquire whether additional tests should be conducted, including methylmalonic acid (MMA) and folate levels, to obtain a comprehensive view.
This conversation can help your doctor determine whether there’s an underlying issue affecting your health and determine the appropriate treatment or supplementation if necessary.
Footnotes
-
Michelle L Vidoni, "Relationship between Homocysteine and Muscle Strength Decline," PubMed Central, 2022. ↩