When taking vitamin E, there are several interactions you need to be aware of:

1. Anticoagulant and Antiplatelet Medications: Vitamin E can inhibit platelet aggregation and interfere with vitamin K-dependent clotting factors, thereby increasing the risk of bleeding. This interaction is particularly significant when taking medications such as warfarin (Coumadin) and other anticoagulants or antiplatelet drugs¹².

2. Simvastatin and Niacin: High doses of vitamin E might reduce the levels of high-density lipoprotein (HDL) cholesterol, which could counteract the effects of medications like simvastatin and niacin used to manage cholesterol levels².

3. Overall Bleeding Risk: Because of its anticoagulant properties, high doses of vitamin E might increase the risk of bleeding during surgical procedures or in individuals with bleeding disorders¹.

Due to these potential interactions, it's crucial to discuss your vitamin E intake with your healthcare provider, especially if you're taking any of the above medications.

Footnotes

1. Office of Dietary Supplements – Vitamin E Interactions ↩ ↩²

2. Vitamin E Deficiency – StatPearls – NCBI Bookshelf ↩ ↩²