Hidradenitis Suppurativa (HS) is a chronic inflammatory skin condition that often requires a multifaceted approach to management. While there are no definitive supplements that can cure HS, some evidence suggests that certain vitamins and minerals may play a supportive role in reducing symptoms and improving overall skin health. Here are some supplements that have been studied in relation to HS:

1. Vitamin D:

   • Several studies indicate that HS patients often have lower levels of vitamin D, which may contribute to the inflammatory processes in the condition[^1][^2]. Supplementing with vitamin D in individuals with deficiency has shown improvement in symptoms in some cases^3.

2. Zinc:

   • Zinc has anti-inflammatory and antioxidant properties, which might be beneficial in managing HS^4. Patients with HS have been found to have lower serum zinc levels, and zinc supplementation has been associated with clinical improvement in certain cases^5.

3. Vitamin A:

   • Vitamin A plays a crucial role in skin health and immune function. There is some evidence suggesting that vitamin A supplementation may help modulate the inflammatory response in HS^6.

4. Vitamin B12:

   • B12 is another nutrient that may have lower levels in HS patients. Monitoring and supplementing B12 levels could potentially support overall treatment strategies^7.

5. Dietary modifications:

   • Adhering to an anti-inflammatory diet, such as the Mediterranean diet, may help reduce the severity of HS symptoms. This diet focuses on the consumption of fruits, vegetables, whole grains, lean proteins, and healthy fats^8.

Overall, while some supplements can support the management of HS, it is crucial to consult with a healthcare provider for personalized advice and to ensure there are no interactions with other treatments.

If you would like to search for specific products containing these supplements, please let me know.

Based on available information, here are the potential interactions and considerations for patients with both Hidradenitis Suppurativa (HS) and diabetes when taking certain supplements:

1. Vitamin D:

   • Generally safe and beneficial for both HS and diabetes. Vitamin D plays essential roles in immune regulation and skin health¹, and supplementation has shown improvement in insulin sensitivity²(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932615/).

2. Zinc:

   • Zinc is useful in managing HS due to its anti-inflammatory properties³(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689602/), and it generally does not negatively interact with diabetes management. Zinc is also known to support insulin function⁴(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724376/).

3. Vitamin A:

   • Vitamin A is crucial for skin health and immune functions⁵(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061923/). High doses should be monitored as they can have adverse effects on liver function and overall health. There is limited evidence of direct negative interactions with diabetes.

4. Vitamin B12:

   • B12 deficiency can be an issue in individuals taking metformin, a common diabetes medication⁶(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691498/). Supplementation is generally recommended and safe.

In summary, vitamin D, zinc, and B12 are generally safe and can be beneficial for patients with both HS and diabetes. However, vitamin A supplementation should be carefully monitored, especially in high doses. Always consult a healthcare provider before starting any new supplement, particularly when managing multiple conditions.

Footnotes

1. Khaled Seetan, "Prevalence of low vitamin D levels in patients with Hidradenitis suppurativa in Jordan: A comparative cross-sectional study," PMC, 2022. ↩

2. Lorraine Jennings, "Metformin use in hidradenitis suppurativa," PubMed, 2025. ↩

3. Alan S. Shen, "Dietary Factors and Hidradenitis Suppurativa", PMC, 2023. ↩

4. No Title Available, "Diabetes and Zinc", PMC, 2023. ↩

5. Sydney Alexis Weir, "Hidradenitis Suppurativa and Five Key Vitamins and Minerals", PMC, 2023. ↩

6. Lorraine Jennings, "Metformin and B12 Deficiency", PMC, 2025. ↩