Does Lactobacillus rhamnosus GG prevent antibiotic-associated diarrhea?
This chat explores evidence from Pillser's research database showing that Lactobacillus rhamnosus GG (LGG) is highly effective in preventing antibiotic-associated diarrhea, reducing risk by about 70% according to a 2018 meta-analysis. Key findings and practical tips for use are discussed.
Does taking Lactobacillus rhamnosus GG help prevent diarrhea while on antibiotics?
Yes, the evidence strongly supports that Lactobacillus rhamnosus GG (LGG) can help prevent antibiotic-associated diarrhea (AAD). Here's what the research shows:
What the Research Says
Pillser's research database contains 2 studies on L. rhamnosus GG and antibiotic-associated diarrhea, both showing beneficial effects, with none showing neutral or harmful results1.
Key Findings:
-
A 2018 meta-analysis found that among several probiotic strains tested, Lactobacillus rhamnosus GG was the most effective for preventing AAD. It reduced the risk of diarrhea by roughly 70% compared to placebo (relative risk ratio of 0.30, 95% CI 0.16–0.5)2.
-
A 2018 review focusing on children concluded that there is a specific recommendation for the use of L. rhamnosus GG (alongside Saccharomyces boulardii) for preventing and treating antibiotic-associated diarrhea3.
Why This Works
Antibiotics kill both harmful and beneficial bacteria in your gut, which can disrupt the normal balance of the microbiome and lead to diarrhea. Taking Lactobacillus rhamnosus GG — a well-studied probiotic strain — helps replenish beneficial bacteria during antibiotic treatment, maintaining gut barrier function and competing with potential pathogens.
Practical Considerations
- LGG is typically taken alongside antibiotics (not at the exact same time, to avoid the antibiotic killing the probiotic — a gap of 2–3 hours is often recommended).
- It is generally well-tolerated and safe for most people, though those who are severely immunocompromised should consult a healthcare provider.
⚠️ Always consult your healthcare provider before starting probiotics, especially if you are seriously ill, immunocompromised, or have a central venous catheter.
Footnotes
-
Pillser research database, Lactobacillus rhamnosus GG and Reduced Antibiotic-Associated Diarrhea. ↩
-
"A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands," Pillser, 2018. ↩
-
"Probiotics and antibiotic-associated diarrhea in children: A review and new evidence on Lactobacillus rhamnosus GG during and after antibiotic treatment," Pillser, 2018. ↩
-