Probiotics and antibiotic-associated diarrhea in children: A review and new evidence on Lactobacillus rhamnosus GG during and after antibiotic treatment.

2018-02
Pharmacological research 128
- Cecilia Mantegazza
- Paola Molinari
- Enza D'Auria
- Micol Sonnino
- Lorenzo Morelli
- Gian Vincenzo Zuccotti

PubMed: 28827186
DOI: 10.1016/j.phrs.2017.08.001

Study Design

Type: Review
Population: children with antibiotic associated diarrhea
Methods: review of systematic reviews and subsequently published randomized controlled trials

Antibiotic associated diarrhea (AAD) is a common complication in childhood in the outpatient and inpatient settings. This review provides up to date information on the use of probiotics in the prevention and treatment of AAD, including that from Clostridium Difficile, in children. The most recently systematic reviews and subsequently published randomized controlleds trials are considered. Different single and multistrain probiotics are described; a specific recommendation for the use of Lactobacillus Rhamnosus GG (LGG) and Saccharomyces boulardii (Sb) emerges. New information on LGG survival under amoxicillin/clavulanate therapy in children is also provided. This information is relevant in view of the frequent use of this molecule in children, its association with AAD, and LGG's sensitivity to penicillin that might make this probiotic ineffective. In spite of a demonstrated positive effect of specific strains of probiotics on AAD, safety issues still remain among which the risk of associated severe infections and of antibiotic resistant gene exchange.

Research Insights

Lactobacillus rhamnosus GG→Reduced Antibiotic-Associated Diarrhea
This review provides up to date information on the use of probiotics in the prevention and treatment of AAD... a specific recommendation for the use of Lactobacillus Rhamnosus GG (LGG) and Saccharomyces boulardii (Sb) emerges.
Effect
Beneficial
Effect size
Moderate
Lactobacillus rhamnosus GG→Reduced Clostridium difficile Infection
This review provides up to date information on the use of probiotics in the prevention and treatment of AAD, including that from Clostridium Difficile, in children.
Effect
Beneficial
Effect size
Small
saccharomyces boulardii→Reduced Antibiotic-Associated Diarrhea
This review provides up to date information on the use of probiotics in the prevention and treatment of AAD... a specific recommendation for the use of Lactobacillus Rhamnosus GG (LGG) and Saccharomyces boulardii (Sb) emerges.
Effect
Beneficial
Effect size
Moderate
saccharomyces boulardii→Reduced Clostridium difficile Infection
This review provides up to date information on the use of probiotics in the prevention and treatment of AAD, including that from Clostridium Difficile, in children.
Effect
Beneficial
Effect size
Small

Adverse Events Reported

Lactobacillus rhamnosus GG→Overall tolerability
safety issues still remain among which the risk of associated severe infections and of antibiotic resistant gene exchange.
Finding
Reported
Severity
Serious adverse event
saccharomyces boulardii→Overall tolerability
safety issues still remain among which the risk of associated severe infections and of antibiotic resistant gene exchange.
Finding
Reported
Severity
Serious adverse event