For managing heartburn, also known as gastroesophageal reflux disease (GERD), a variety of supplements and natural remedies could be beneficial. Here are some options that have been studied:

1. Melatonin: Studies have shown that melatonin can help reduce GERD symptoms due to its inhibitory effects on gastric acid secretion and nitric oxide biosynthesis, which can reduce lower esophageal sphincter relaxation, a key mechanism of reflux¹.

2. Ginger: Known for its gastrointestinal benefits, ginger can help reduce overall swelling and irritation in the esophagus, potentially alleviating heartburn².

3. DGL (Deglycyrrhizinated Licorice): Chewing DGL can help boost enzyme production, aiding digestion and providing a protective barrier against stomach acid in the esophagus³.

4. Peppermint Oil: Although peppermint can relax the esophageal sphincter and worsen symptoms if not used carefully, enteric-coated peppermint oil might help by preventing its release until it reaches the intestines⁴.

5. Combination Supplements: A formulation containing melatonin, l-tryptophan, vitamin B6, folic acid, vitamin B12, methionine, and betaine has shown promise in reducing GERD symptoms. A study indicated complete regression of symptoms in patients taking this combination compared to those taking omeprazole⁵.

Keep these supplements in mind as potential options to manage heartburn. If you want product recommendations for any of the above, please let me know!

Footnotes

1. PMC Study on Melatonin ↩

2. PubMed Article on Herbs for GERD Management ↩

3. PMC Evidence-based Review ↩

4. PMC Integrated Traditional Herbal Medicine ↩

5. PubMed Study on Supplement Combination ↩