When it comes to probiotics, their efficacy and safety can be impacted by factors such as storage conditions, exposure to air, and time after opening, even if the expiration date has not yet passed.

1. Potency Over Time: Probiotics, like Bifidobacterium, can gradually lose their potency over time, especially after being exposed to air and moisture when the bottle is opened. This can affect their ability to provide the intended health benefits¹.

2. Storage Conditions: The storage conditions play a crucial role. If the probiotics were stored in a cool, dry place and the packaging instructions (such as refrigeration, if required) were followed, they are more likely to maintain their potency. However, if they were stored in less than ideal conditions (e.g., in a warm or humid environment), their effectiveness could be compromised².

3. Visual and Sensory Inspection: Before using the probiotics, you should check for any visible signs of spoilage or changes in smell and color. If there's any doubt or noticeable changes, it may be best to discard them.

4. Consultation with a Healthcare Provider: If you're still uncertain about the safety and effectiveness of using these probiotics, it's wise to consult with a healthcare provider for personalized advice.

Despite the expiration date indicating a later timeframe, these factors can influence whether the product is still suitable for consumption.

Footnotes

1. Saarela, M., Mogensen, G., Fondén, R., Mättö, J., & Mattila-Sandholm, T. (2000). Probiotic bacteria: safety, functional and technological properties. Journal of Biotechnology, 84(3), 197-215. ↩

2. Weese, J. S., & Martin, H. (2011). Assessment of commercial probiotic bacterial contents and label accuracy. Canadian Veterinary Journal, 52(1), 43-46. ↩