Your persistent fatigue, despite supplementing with vitamin B12, may have multiple causes, including vitamin deficiencies or other underlying conditions. While vitamin B12 is crucial for energy production and red blood cell formation, and a deficiency can lead to fatigue¹, there are factors such as absorption issues that might affect B12 levels.

Vitamin B12 needs to combine with intrinsic factor for absorption, and any deficit in intrinsic factor can lead to poor absorption². This could mean that although you're taking a vitamin B12 supplement, your body might not be absorbing it effectively. Sublingual B12 supplements have been suggested to improve absorption, but the evidence is not definitive¹.

Regarding omega-3 deficiency, there isn't a well-documented direct connection between omega-3 deficiency and fatigue³. However, omega-3 fatty acids are essential for various bodily functions, including brain health and may contribute to overall well-being, potentially impacting symptoms of fatigue indirectly³.

If you continue to struggle with fatigue, it might be useful to explore other possible causes or consult with a healthcare provider to evaluate your vitamin levels and absorption capabilities comprehensively.

Footnotes

1. Vitamin B12 Overview, Harvard T.H. Chan School of Public Health ↩ ↩²

2. Vitamin B12 Absorption, Harvard T.H. Chan School of Public Health ↩

3. Omega-3 Fatty Acids Health Professional Fact Sheet, Office of Dietary Supplements ↩ ↩²