Several supplements have been clinically studied for their effectiveness in alleviating symptoms of Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME). Here are some that have shown promising results:

1. Coenzyme Q10 (CoQ10) and NADH:

   • CoQ10 and NADH are both antioxidants and play a role in cellular energy production. Studies have shown that the combination of these supplements can lead to significant reductions in fatigue and improvements in health-related quality of life¹².

2. Selenium and CoQ10:

   • A combination of selenium and CoQ10 has been found to improve overall fatigue severity and global quality of life in CFS patients. This combination also showed effects on oxidative stress and inflammation markers³.

3. Beta-Glucan with Multivitamins:

   • Yeast-derived beta-glucan combined with multivitamins (including vitamin D3, vitamin B6, and zinc) has been shown to significantly improve cognitive fatigue in CFS patients⁴.

4. Probiotics:

   • Probiotics may help to balance gut microbiota, which can be beneficial in reducing some symptoms of CFS. Improvements in fatigue have been observed in some studies⁵.

5. High Cocoa Polyphenol Rich Chocolate:

   • This type of chocolate, which is high in polyphenols, has been shown to have a positive effect on fatigue levels in CFS patients. This may be due to its antioxidant properties⁵.

While these supplements seem promising, it is important for individuals with CFS to consult with their healthcare providers before starting any new supplement regimen to ensure safety and appropriateness for their specific condition.

Footnotes

1. Clinical Nutrition, 2016 ↩

2. Nutrients, 2021 ↩

3. Antioxid Redox Signal, 2022 ↩

4. Nutrients, 2023 ↩

5. J Hum Nutr Diet, 2017 ↩ ↩²