The quest for longevity through supplements is a topic of increasing interest. Various dietary and natural supplements have been studied for their potential to promote healthy aging and extend lifespan by targeting biological aging processes and nutrient-sensing pathways¹². Here are some of the commonly recognized supplements associated with longevity benefits:

1. Resveratrol: Found in grapes, this compound is known for its antioxidant properties and has shown potential in activating sirtuin proteins that are linked to extended lifespans².

2. Curcumin: Derived from turmeric, curcumin has anti-inflammatory and antioxidant effects that may play a role in slowing aging processes³.

3. Coenzyme Q10 (CoQ10): A crucial element in cellular energy production, CoQ10 has been studied for its potential to improve heart health and slow aspects of the aging process¹.

4. Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Both are precursors to NAD+, a molecule essential for cellular energy production, and have been linked to anti-aging effects through their ability to enhance cellular repair processes².

5. Omega-3 Fatty Acids: Known for their benefits to heart health, omega-3s may also have a role in reducing inflammation and promoting brain health as we age³.

6. Spermidine: Found in various foods, spermidine promotes autophagy, a cellular cleanup process that is important for maintaining cell health as we age².

7. Quercetin: This flavonoid has antioxidant properties and may support cardiovascular health and reduce the effects of aging³.

8. Pterostilbene: A compound closely related to resveratrol, pterostilbene has shown potential in improving metabolic function and longevity³.

9. Astragalus Root: Traditionally used in Chinese medicine, it may provide immune support and has compounds that could improve telomere strength².

10. Green Tea Extract (EGCG): Known for its rich content of catechins, green tea extract has potent antioxidant properties that support longevity³.

These supplements are believed to promote longevity primarily by influencing key aging pathways, like nutrient sensing and cellular repair mechanisms¹²³.

Footnotes

1. Ye Chen, "Dietary Supplements and Natural Products: An Update on Their Clinical Effectiveness," PMC, 2022. ↩ ↩² ↩³

2. Ji-Kai Liu, "Antiaging agents: safe interventions to slow aging and healthy life span extension," PMC, 2022. ↩ ↩² ↩³ ↩⁴ ↩⁵ ↩⁶

3. Lulu Gao, "Antiaging effects of dietary supplements and natural products," PMC, 2023. ↩ ↩² ↩³ ↩⁴ ↩⁵ ↩⁶