Nicotinamide Mononucleotide (NMN) is a supplement that has garnered attention for its potential benefits in boosting Nicotinamide Adenine Dinucleotide (NAD+) levels in the body. NAD+ is a crucial coenzyme involved in various metabolic processes and is believed to play a role in aging and cellular function.

Benefits of NMN:

1. Increased NAD+ Levels: Supplementation with NMN has been shown to statistically significantly increase blood NAD+ concentrations, particularly at doses of 600 mg and 900 mg daily¹.
2. Improved Physical Performance: Trials have demonstrated that NMN can enhance physical performance, as evidenced by increased walking distances in tests like the six-minute walking test¹.
3. Potential Anti-Aging Effects: NMN supplementation has been associated with stabilizing biological age metrics compared to baseline levels in some studies¹.

Safety and Tolerability:

NMN is generally considered safe, with clinical trials revealing no significant safety issues or adverse events for doses up to 900 mg daily. Participants in these studies tolerated the supplement well¹.

NMN offers promising benefits in terms of enhancing NAD+ concentrations and potentially improving healthspan, though further research, particularly long-term studies, is needed to fully understand its effects in humans¹.

Footnotes

1. Lin Yi, "The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults," PubMed, 2022. ↩ ↩² ↩³ ↩⁴ ↩⁵