Taurine, a sulfur-containing amino acid, has shown potential benefits related to longevity and aging. Recent studies suggest that taurine supplementation could play a role in promoting longevity and healthier aging in various organisms.

1. Reduction of Cellular Senescence and DNA Damage: Taurine supplementation has been found to reduce cellular senescence, protect against telomerase deficiency, and decrease DNA damage¹².

2. Mitochondrial Health and Antioxidant Properties: Taurine helps in maintaining mitochondrial function and acts as an antioxidant, reducing oxidative stress, which is linked with aging³⁴.

3. Improvement in Muscle Function: Long-term taurine supplementation in rodents was shown to improve skeletal muscle function and exercise capacity, which often decline with age⁵.

4. Decrease in Inflammation and Oxidative Stress: Taurine administration in aged mice was found to reduce inflammation and oxidative stress, which are contributors to age-related muscle loss and overall decline⁶.

5. Epidemiological Evidence: There is also epidemiological data indicating that higher taurine levels are associated with lower rates of cardiovascular diseases and longer lifespans, such as seen in the Japanese population⁷.

6. Healthspan Enhancement: In studies involving mice and monkeys, taurine supplementation increased healthspan, defined as the period of life spent in good health, free from chronic diseases⁸.

Further clinical trials in humans are warranted to confirm these findings and fully determine the potential of taurine as a longevity supplement⁹.

Footnotes

1. Parminder Singh, "Taurine deficiency as a driver of aging," PubMed, 2023. ↩

2. Ayesha Sheikh, "Taurine as a potential anti-ageing therapy," NCBI, 2020. ↩

3. Gaetano Santulli, "Functional Role of Taurine in Aging and Cardiovascular Health," PubMed, 2023. ↩

4. Baliou S., et al., "Protective role of taurine against oxidative stress," NCBI, 2021. ↩

5. Yun Ma, "Effects of long-term taurine supplementation on age-related changes in skeletal muscle function," PubMed, 2021. ↩

6. Alessandra Barbiera, "Taurine Administration Counteracts Aging-Associated Impingement of Skeletal Muscle Regeneration," NCBI, 2022. ↩

7. Yukio Yamori, "Taurine as the nutritional factor for the longevity of the Japanese," PubMed, 2009. ↩

8. Parminder Singh, "Taurine deficiency as a driver of aging," NCBI, 2023. ↩

9. Kwok M. Ho, "Flattening the biological age curve by improving metabolic health," NCBI, 2023. ↩

There are a few studies that have investigated the effectiveness of low-dose CBD (10mg) in humans. Here are some key findings:

1. Anxiety and Stress: A study on the effects of CBD in humans found that low to moderate doses (generally around 10mg to 300mg) may help reduce anxiety. For instance, single doses of 10mg to 300mg of CBD have been found to reduce anxiety in both public speaking and general anxiety disorder contexts¹².

2. Psychiatric Disorders: Another study indicated that low to moderate doses of CBD could have potential benefits for psychiatric conditions like anxiety disorders. The anxiolytic (anxiety-reducing) effects were observed in clinical trials where CBD was administered in doses as low as 10mg³.

3. Epilepsy and Seizure Management: While most of the research on epilepsy involves higher doses (up to 20mg/kg per day), there are clinical trials that have used lower doses effectively. For example, a lower dose of 10mg/kg per day showed a reduction in seizure frequency in some patients⁴.

4. Safety and Tolerability: Generally, studies have shown that CBD is well-tolerated even at higher doses. However, it's also noted that smaller doses (like 10mg) tend to have fewer and less severe side effects compared to higher doses⁵.

5. Pain Management: Limited evidence exists on the efficacy of low doses of CBD for pain management. Some studies suggest that low doses (10mg or less) might not be as effective as higher doses for conditions like chronic pain⁶.

While these studies are promising, more research, particularly long-term studies, are needed to fully understand the therapeutic potential and optimal dosing of low-dose CBD in humans.

Footnotes

1. Blessing EM, Steenkamp MM, Manzanares J, Marmar CR. "Cannabidiol as a Potential Treatment for Anxiety Disorders." PMC, 2015. ↩

2. Millar SA, Stone NL, Yates AS, O'Sullivan SE. "A Systematic Review of Cannabidiol Dosing in Clinical Populations." PMC, 2019. ↩

3. Larsen C, Shahinas J. "Dosage, Efficacy and Safety of Cannabidiol Administration in Adults: A Systematic Review of Human Trials." PMC, 2020. ↩

4. Silvestro S, Mammana S, Cavalli E, Bram Anti A. "Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials." PMC, 2019. ↩

5. Iffland K, Grotenhermen F. "An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies." PMC, 2017. ↩

6. Arnold JC, McGregor I, McCartney D, Suraev A. "The Safety and Efficacy of Low Oral Doses of Cannabidiol: An Evaluation of the Evidence." PMC, 2022. ↩