Nicotinamide Mononucleotide (NMN) is a supplement that has garnered attention for its potential anti-aging benefits and ability to improve overall health. Here are some of the key findings regarding NMN supplementation:

1. Increases NAD+ Levels: NMN acts as a precursor to nicotinamide adenine dinucleotide (NAD+), a critical coenzyme involved in energy metabolism and cellular repair. Supplementation with NMN has been shown to significantly increase NAD+ levels in blood¹.

2. Anti-Aging Effects: NMN may delay aging processes by improving mitochondrial function, enhancing insulin sensitivity, and reducing inflammation. Studies suggest that NMN can improve physical performance, reduce biological age markers, and mitigate age-related dysfunctions in animal models²³.

3. Safety and Tolerability: Clinical trials have generally found NMN to be safe and well-tolerated, with doses up to 900 mg per day demonstrating no significant adverse effects⁴.

4. Physical and Cognitive Benefits: Trials on human participants indicate that NMN supplementation can enhance physical performance, improve muscle function, and possibly benefit cognitive functions⁵⁶.

5. Gaps in Research: While animal studies and early human trials are promising, comprehensive long-term studies in larger and more diverse human populations are still lacking to fully confirm the efficacy and safety of NMN⁷.

In conclusion, NMN appears to be a promising supplement for boosting NAD+ levels and offering potential anti-aging benefits. However, more extensive and long-term human studies are required to fully validate these effects.

Footnotes

1. Harshani Nadeeshani, "Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns," NCBI, 2021. ↩

2. Huan Wang, "Nicotinamide Mononucleotide Supplementation Improves Mitochondrial Dysfunction and Rescues Cellular Senescence by NAD+/Sirt3 Pathway in Mesenchymal Stem Cells," NCBI, 2025. ↩

3. Christopher Shade, "The Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule," NCBI, 2020. ↩

4. Lin Yi, "The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults," NCBI, 2022. ↩

5. Masaki Igarashi, "Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men," NCBI, 2022. ↩

6. Mijin Kim, "Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults," NCBI, 2022. ↩

7. Qin Song, "The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update," NCBI, 2022. ↩