Lithium is widely recognized for its use in treating bipolar disorder and related psychiatric conditions, but recent studies suggest it may also have significant benefits for health and longevity.

1. Longevity and Mortality: Research has shown that lithium supplementation can extend lifespan in various animal models, and there is a positive correlation between low-dose lithium in drinking water and longevity in humans¹². In a large observational study using data from the UK Biobank, lithium supplementation was linked to decreased mortality rates among individuals diagnosed with affective disorders¹.

2. Telomere Length: Lithium has been found to increase the length of telomeres, which is crucial for cellular longevity and health. Telomeres are DNA-protein structures at the ends of chromosomes that protect them from deterioration³.

3. Cognitive Function and Dementia: There is evidence that lithium use is associated with a lower incidence of dementia and preservation of cognitive function in older adults³.

4. Healthspan Improvements: In addition to extending lifespan, lithium has shown modest benefits in healthspan, improving factors such as motor performance, body weight, and glucose tolerance⁴. It has beneficial effects on cardiovascular, metabolic, musculoskeletal, and cognitive functions as well as on inflammatory and antioxidant processes⁵.

Despite these potential benefits, it's important to note that lithium has a narrow therapeutic window, and its use must be carefully monitored to avoid adverse effects. The doses used in these studies are typically lower than those used for psychiatric treatment.

If you are considering lithium supplementation for health and longevity, it is essential to consult with a healthcare professional to determine the appropriate dosage and to monitor for any potential side effects.

Footnotes

1. Lithium treatment extends human lifespan: findings from the UK Biobank - PubMed ↩ ↩²

2. Low-dose lithium uptake promotes longevity in humans and metazoans - PubMed ↩

3. The New News about Lithium: An Underutilized Treatment in the United States ↩ ↩²

4. Lithium can mildly increase health during ageing but not lifespan in mice ↩

5. Beyond its Psychiatric Use: The Benefits of Low-dose Lithium Supplementation - PubMed ↩