Based on the research data available on supplements that promote human health and longevity, here is a comprehensive supplement formula with 15 ingredients along with their clinically proven doses:

1. Nicotinamide Mononucleotide (NMN):

   • Dose: 250-500 mg/day
   • Function: Increases NAD+ biosynthesis, improving mitochondrial function, insulin sensitivity¹.

2. Curcumin:

   • Dose: 500-2,000 mg/day (with black pepper extract for better absorption)
   • Function: Anti-inflammatory, antioxidant properties².

3. Resveratrol:

   • Dose: 200-500 mg/day
   • Function: Activates sirtuins, mimicking caloric restriction benefits³.

4. Coenzyme Q10 (CoQ10):

   • Dose: 100-200 mg/day
   • Function: Enhances mitochondrial function, reducing oxidative stress⁴.

5. Omega-3 Fatty Acids (EPA and DHA):

   • Dose: 1,000-2,000 mg/day
   • Function: Improves cardiovascular health, anti-inflammatory properties⁵.

6. Vitamin D3 (Cholecalciferol):

   • Dose: 1,000-2,000 IU/day
   • Function: Bone health, immune function⁶.

7. Magnesium:

   • Dose: 200-400 mg/day
   • Function: Nervous system function, muscle health⁷.

8. Astaxanthin:

   • Dose: 4-12 mg/day
   • Function: Potent antioxidant, protects skin health⁸.

9. Alpha-Lipoic Acid (ALA):

   • Dose: 300-600 mg/day
   • Function: Reduces oxidative damage, improves insulin sensitivity⁹.

10. Quercetin:

    • Dose: 500-1,000 mg/day
    • Function: Antioxidant, anti-inflammatory, senolytic activity¹⁰.

11. Vitamin C (Ascorbic Acid):

    • Dose: 500-1,000 mg/day
    • Function: Antioxidant, immune support¹¹.

12. Vitamin E (Mixed Tocopherols):

    • Dose: 100-400 IU/day
    • Function: Antioxidant, cardiovascular health¹².

13. Zinc:

    • Dose: 10-40 mg/day
    • Function: Immune support, skin health¹³.

14. Selenium:

    • Dose: 100-200 mcg/day
    • Function: Antioxidant, thyroid function¹⁴.

15. L-Theanine:

    • Dose: 100-200 mg/day
    • Function: Reduces stress, enhances cognitive function¹⁵.

These ingredients and their doses are based on clinical studies that have evaluated their effects on human health and longevity. Always consult with a healthcare provider before starting any new supplement regimen.

Footnotes

1. Harshani Nadeeshani et al., "Nicotinamide mononucleotide (NMN) as an anti-aging health product - Promises and safety concerns," J Adv Res, 2022. ↩

2. Lulu Gao et al., "Antiaging effects of dietary supplements and natural products," Front Pharmacol, 2023. ↩

3. Ye Chen et al., "Dietary Supplements and Natural Products: An Update on Their Clinical Effectiveness," Front Genet, 2022. ↩

4. Lulu Gao et al., "Antiaging effects of dietary supplements and natural products," Front Pharmacol, 2023. ↩

5. David R Thomas, "Vitamins in Aging, Health, and Longevity," PMC2682456, 2024. ↩

6. Abdullah Al Mahmud et al., "Clinically proven natural products, vitamins, and mineral in boosting up immunity," Heliyon, 2023. ↩

7. Lulu Gao et al., "Antiaging effects of dietary supplements and natural products," Front Pharmacol, 2023. ↩

8. Bruce N. Ames, "Prolonging healthy aging: Longevity vitamins and proteins," PNAS, 2018. ↩

9. Ye Chen et al., "Dietary Supplements and Natural Products: An Update on Their Clinical Effectiveness," Front Genet, 2022. ↩

10. Bruce N. Ames, "Prolonging healthy aging: Longevity vitamins and proteins," PNAS, 2018. ↩

11. Abdullah Al Mahmud et al., "Clinically proven natural products, vitamins, and mineral in boosting up immunity," Heliyon, 2023. ↩

12. David R Thomas, "Vitamins in Aging, Health, and Longevity," PMC2682456, 2024. ↩

13. Abdullah Al Mahmud et al., "Clinically proven natural products, vitamins, and mineral in boosting up immunity," Heliyon, 2023. ↩

14. Lulu Gao et al., "Antiaging effects of dietary supplements and natural products," Front Pharmacol, 2023. ↩

15. Mónika Fekete, "Improving Cognitive Function with Nutritional Supplements in Aging," PMC10746024, 2023. ↩