Several supplements have shown promising results in reducing stress based on various studies and reviews. Here are a few notable examples:

1. Ashwagandha: This herb is one of the most well-researched supplements for stress reduction¹². Studies have shown that Ashwagandha can lower stress and anxiety levels, improve sleep quality, and reduce fatigue and cortisol levels. Doses of 500 to 600 mg per day appear to be more effective¹.

2. Vitamin B6: Research indicates that high doses of Vitamin B6 can significantly reduce stress, anxiety, and depressive symptoms³. It works primarily through its impact on neurotransmitter function, including serotonin and GABA production, which help calm the nervous system³.

3. Magnesium: Magnesium supplementation, particularly when combined with Vitamin B6, has been found to reduce stress and improve quality of life in healthy adults experiencing stress⁴⁵.

4. Rhodiola Rosea: This adaptogenic herb has been found to decrease mental fatigue, depression, and improve recovery from stress-induced physical fatigue⁶. It has shown effectiveness in alleviating symptoms of burnout and improving general stress scores⁶.

5. Vitamin C: High-dose sustained-release Vitamin C has also shown efficacy in reducing anxiety and controlling blood pressure responses to stress⁷.

Taking these supplements may help reduce stress levels, but it's essential to consult with a healthcare provider before starting any new supplement to ensure that it does not interact with other medications or health conditions.

Footnotes

1. NIH Office of Dietary Supplements - Ashwagandha ↩ ↩²

2. Mayo Clinic Q and A: Ashwagandha ↩

3. Vitamin B6 and Anxiety ↩ ↩²

4. McCabe, D. - Supplement impact on stress levels in women ↩

5. Noah, L. - Magnesium and B6 supplementation ↩

6. Burns, J. - Rhodiola for stress ↩ ↩²

7. McCabe, D. - Vitamin C and stress ↩