When considering supplements to calm the amygdala and activate the parasympathetic nervous system, the options include magnesium, ashwagandha, and phosphatidylserine.

1. Magnesium is well-known for its role in numerous bodily functions, including the regulation of neurotransmitters, which can affect mood and stress levels. It can help induce relaxation and reduce anxiety, potentially supporting the activation of the parasympathetic nervous system. However, I couldn't find specific information directly linking magnesium to calming the amygdala or specifically activating the parasympathetic nervous system.

2. Ashwagandha is an adaptogen often used to help with stress and anxiety. Clinical studies suggest that ashwagandha can help reduce stress-related symptoms and anxiety, as well as potentially improve sleep quality. These effects can be associated with a calming influence on the nervous system, potentially helping activate the parasympathetic nervous system¹².

3. Phosphatidylserine may help reduce cortisol levels and improve mood, as some studies indicate its potential benefit in managing depression. This suggests it might have effects that contribute to calming the nervous system³⁴.

Based on the information, ashwagandha seems to be most directly associated with reducing stress and anxiety and possibly activating the parasympathetic nervous system, which could help calm the amygdala.

Footnotes

1. MedlinePlus Supplements, "Ashwagandha," MedlinePlus. ↩

2. "Ashwagandha: Is it helpful for stress, anxiety, or sleep?" Office of Dietary Supplements. ↩

3. Teruhisa Komori, "The Effects of Phosphatidylserine and Omega-3 Fatty Acid-Containing Supplement on Late Life Depression," PubMed Central. ↩

4. Ibid. ↩