Alpha-GPC (alpha-glycerylphosphorylcholine) is considered legitimate due to its documented benefits in several areas of mental and physical health:

1. Cognitive Benefits: Alpha-GPC is known to increase the release of the neurotransmitter acetylcholine, which facilitates learning and memory¹. Several studies have shown that it can improve cognitive function in individuals with cognitive impairments, such as those with mild to moderate dementia²³. However, there is limited evidence supporting its cognitive enhancement effects in healthy individuals⁴.

2. Physical Performance: Alpha-GPC has been shown to act as an ergogenic aid, potentially enhancing physical performance. It may improve vertical jump power, peak bench press force, and peak power in trained cyclists⁵⁶⁷. Some studies suggest that its effects might depend on the dosage and duration of supplementation⁸.

3. Neurological Health: Alpha-GPC can be particularly beneficial for individuals recovering from cerebrovascular accidents (strokes) as it supports improved cognitive function and behavior⁹.

However, there are some caveats:

• Potential Adverse Effects: There is evidence that links Alpha-GPC supplementation to increased risk of atherosclerosis and stroke due to its conversion to trimethylamine N-oxide (TMAO), a pro-atherogenic substance¹⁰¹¹.

Overall, Alpha-GPC is a well-researched supplement with clear benefits for cognitive health and some aspects of physical performance. However, potential users should consider the possible adverse effects and consult with healthcare professionals before starting supplementation.

Footnotes

1. Effects on mood, cognitive function, power, speed, and agility ↩

2. Cognitive dysfunctions in dementia ↩

3. Adult-onset cognitive impairment ↩

4. Choline supplementation in cognitive functions ↩

5. Physical and psychomotor performance ↩

6. Explosive strength and fatigue resistance ↩

7. Isometric strength and peak power ↩

8. Doses and performance ↩

9. Cognitive function post-stroke ↩

10. Atherosclerosis promotion ↩

11. Gut microbial community and inflammation ↩