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Comparing Mitocore and Phosphatidylserine: Benefits Beyond a Multivitamin

This chat discusses the benefits of Mitocore ingredients, highlighting mitochondrial enhancement and cognitive support, and compares these with Phosphatidylserine's cognitive benefits and stress reduction effectiveness.

  • Does the following list of ingredients for mitocore show a benefit beyond a multivitamin? Feed
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    What efficacy does this supplement Phosphatidyl Serine SF have

    Phosphatidylserine (PS) is a phospholipid that is commonly found in cell membranes, especially in the brain. Its supplementation is marketed primarily for its potential cognitive benefits.

    Cognitive Function and Memory
    Improvement in Cognitive Functions:

    Some clinical trials have shown modest improvements in cognitive functions with phosphatidylserine supplementation1. It is particularly noted for supporting memory formation, consolidation, recall, and other cognitive processes2.
    Age-Associated Memory Impairment:

    The effects on age-associated memory impairment (AAMI) have been mixed. A notable clinical trial showed no significant differences in learning and memory outcomes between placebo and PS treatment groups in elderly subjects with memory complaints3.
    However, other studies have demonstrated that phosphatidylserine supplementation could improve memory functions, particularly delayed verbal recall, in elderly individuals4.
    Effects on Depression and Stress
    Late Life Depression:

    Combining phosphatidylserine with omega-3 fatty acids (DHA and EPA) has shown improvements in late-life depression symptoms. This improvement could be linked to normalization of basal levels and circadian rhythm of salivary cortisol5.
    Stress Response:

    Phosphatidylserine has been shown to influence neuroendocrine responses, including reducing cortisol response to stress and overtraining in athletes6.
    Exercise Performance
    Physical Endurance and Recovery:
    Supplementation with phosphatidylserine has been linked to enhanced exercise capacity and reduced perceived muscle soreness in high-intensity physical activities6.
    Anti-Inflammatory and Neuroprotective Effects
    Anti-Inflammation:
    Phosphatidylserine plays a role in regulating inflammation in the brain and may serve as a therapeutic agent in neurodegenerative and neurodevelopmental diseases7.
    Safety and Tolerability
    Well-Being:
    Studies indicate that phosphatidylserine is generally well-tolerated and does not lead to significant adverse effects8.
    In summary, Phosphatidylserine shows potential benefits for cognitive enhancement, especially in memory-related functions and stress reduction, although more rigorous studies are needed to confirm its efficacy across various applications.

    Phosphatidylserine & Your Brain | Alzheimer’s Drug Discovery Foundation ↩

    Phosphatidylserine and the human brain - PubMed ↩

    The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment - PubMed ↩

    Soybean-Derived Phosphatidylserine Improves Memory Function ↩

    The Effects of Phosphatidylserine and Omega-3 on Depression ↩

    Effects of phosphatidylserine supplementation on exercising humans ↩ ↩2

    Phosphatidylserine, inflammation, and central nervous system diseases ↩

    Phosphatidylserine in the Brain: Metabolism and Function ↩

    Does the supplement mitocore with Serving Size: 4 Capsules

    Amount Per Serving
    Vitamin A (from 5,000 IU
    as Natural Beta Carotene) 1,500 mcg
    Vitamin C (as Ascorbic Acid USP) 250 mg
    Vitamin D (D3 as Cholecalciferol) 25 mcg (1,000 IU)
    Thiamin (Vitamin B1)
    (from Thiamine Hydrochloride USP) 15 mg
    Riboflavin (Vitamin B2 USP) 15 mg
    Niacin (as Niacinamide USP) 15 mg
    Vitamin B6
    (as Pyridoxine Hydrochloride USP) 15 mg
    Folate (from 800 mcg as
    Quatrefolic® (6S)-5-Methyltetrahydrofolic acid glucosamine salt) 1,360 mcg DFE
    Vitamin B12 (as Methylcobalamin) 250 mcg
    Biotin 50 mcg
    Pantothenic Acid
    (as d-Calcium Pantothenate USP) 15 mg
    Choline (as Choline Bitartrate) 15 mg
    Calcium (as Calcium Citrate USP) 75 mg
    Iodine (from Potassium Iodide) 37 mcg
    Magnesium (as DiMagnesium Malate) 75 mg
    Zinc (as TRAACS® Zinc
    Bisglycinate Chelate) 5 mg
    Selenium (as Selenium
    Glycinate Complex) 75 mcg
    Manganese (as TRAACS®
    Manganese Bisglycinate Chelate) 1 mg
    Chromium (as O-polynicotinate)‡ 50 mcg
    Potassium (as Potassium Citrate USP) 30 mg
    N-Acetyl-L-Cysteine USP 600 mg
    Acetyl L-Carnitine Hydrochloride 500 mg
    Malic Acid (as DiMagnesium Malate) 215 mg
    Alpha Lipoic Acid 200 mg
    Mixed Tocopherols 50 mg
    Green Tea Leaf Extract (Standardized
    to contain 45% EGCg (Epigallocatechin gallate)) 45 mg
    Broccoli Seed Extract (TrueBroc®
    )
    (Standardized to contain 13% Sulforaphane Glucosinolate) 40 mg
    Inositol NF 15 mg
    trans -Resveratrol (from
    Polygonum cuspidatum (Roots)) 10 mg

    Other Ingredients: Natural Vegetable Capsules, Ascorbyl Palmitate, Magnesium Stearate, Magnesium Silicate and Silicon Dioxide.

  • Based on the research, the ingredients in Mitocore offer several benefits beyond those typically found in a standard multivitamin:

    Mitochondrial Function Enhancement

    • N-Acetyl-L-Cysteine (NAC): Acts as a precursor to glutathione, a powerful antioxidant that helps protect mitochondria from oxidative damage1.
    • Acetyl L-Carnitine: Facilitates the transport of fatty acids into mitochondria to be utilized for energy production, which can enhance mitochondrial function2.
    • Alpha Lipoic Acid: Functions as a potent antioxidant and can help regenerate other antioxidants within the mitochondria3.

    Antioxidant Support

    • Vitamin C, Vitamin E (Mixed Tocopherols), and Alpha Lipoic Acid: Provide significant antioxidant protection, which is essential for maintaining mitochondrial integrity4.
    • Green Tea Extract (EGCg) and Broccoli Seed Extract (Sulforaphane Glucosinolate): These compounds also provide strong antioxidant support5.

    Cognitive and Cellular Health

    • Inositol and Choline: Important for cell membrane health and signal transduction6.
    • trans-Resveratrol: Known for its anti-inflammatory and antioxidant properties, which can also support mitochondrial health7.

    Cofactors and Essential Nutrients

    • Magnesium, Zinc, Selenium, and Manganese: Vital cofactors for various enzymatic reactions in the mitochondria8.

    Comprehensive Coverage

    • Multiple Vitamins (A, B-complex, C, D3, E): Ensure comprehensive nutrient support, aiding in overall cell and mitochondrial health9.
    • Broccoli Seed Extract and Green Tea Extract: Provide specific phytochemicals that support detoxification pathways and mitochondrial health10.

    In summary, Mitocore includes specific ingredients such as NAC, Acetyl L-Carnitine, Alpha Lipoic Acid, Green Tea Extract, and Broccoli Seed Extract—designed to enhance mitochondrial efficiency, provide antioxidant defense, and support cellular health, which are beyond the typical scope of most multivitamins11.

    Efficacy of Phosphatidylserine

    Phosphatidylserine has documented benefits primarily related to cognitive function:

    • Memory and Cognitive Performance: Some studies have shown improvements in memory and cognitive functions in the elderly and individuals with cognitive impairments1213.
    • Stress Reduction: Supplementation has shown potential in reducing cortisol and stress responses14.
    • Attention-Deficit Hyperactivity Disorder (ADHD): Studies suggest potential benefits in reducing symptoms of ADHD15.

    Conclusion

    While standard multivitamins provide essential nutrients, Mitocore includes specialized ingredients that target mitochondrial function and antioxidant protection, offering benefits that extend beyond what typical multivitamins provide.

    Footnotes

    1. Katherine M. Shaum, "Nutrition And Reproduction: Is There Evidence To Support A 'Fertility Diet' To Improve Mitochondrial Function?", PMC, 2024. ↩

    2. Idem. ↩

    3. Idem. ↩

    4. Idem. ↩

    5. Idem. ↩

    6. Idem. ↩

    7. Idem. ↩

    8. Garth L. Nicolson, "Mitochondrial Dysfunction and Chronic Disease: Treatment With Natural Supplements", PMC, 2024. ↩

    9. Idem. ↩

    10. Sahar Aghakhani, "Metabolic reprogramming in Rheumatoid Arthritis Synovial Fibroblasts: A hybrid modeling approach", PMC, 2022. ↩

    11. Idem. ↩

    12. S Hirayama, "The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial", PubMed, 2013. ↩

    13. Margret I. Moré, "Positive Effects of Soy Lecithin-Derived Phosphatidylserine plus Phosphatidic Acid on Memory, Cognition, Daily Functioning, and Mood in Elderly Patients with Alzheimer’s Disease and Dementia", PMC, 2014. ↩

    14. Veronika Vakhapova, "Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial", PMC, 2014. ↩

    15. S Hirayama, ibid. ↩

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