Here is a detailed breakdown of how the supplementation of each mentioned substance may individually affect the kidneys based on available authoritative information:

Tongkat Ali (Eurycoma longifolia)

Tongkat Ali, commonly used for its aphrodisiac and anti-aging effects, is generally considered safe regarding renal function at normal doses. Studies have shown no adverse changes in liver and renal function tests with typical daily dosages¹. However, genotoxic potential has been noted at very high doses².

Ashwagandha

Ashwagandha has been associated with liver injury in some cases, which might indirectly affect kidney function due to its role in filtering blood³. Patients with pre-existing conditions should use caution⁴.

Fadogia agrestis

Research is limited on Fadogia agrestis' direct impact on kidney function. However, since it has shown pharmacological effects on the reproductive system in animals, use with caution is advisable due to the lack of robust safety data⁵.

Korean Red Panax Ginseng

Ginseng can have various effects on the kidneys, especially under conditions of abuse or misuse, such as potential cardiovascular and renal toxicity⁶. It may also interact with certain medications, impacting renal function⁶.

Acetyl L-Carnitine

There is limited data specifically on acetyl L-carnitine’s impact on kidney function. However, L-carnitine metabolism involves renal reabsorption, and supplementing it could lead to an increase in urinary excretion if renal function is impaired⁷.

L-Carnitine L-Tartrate

Similar to acetyl L-carnitine, L-carnitine L-tartrate requires efficient kidney function to maintain homeostasis. High supplementation may result in higher urinary excretion if renal reabsorption is saturated⁷.

Vitamin C

High doses of Vitamin C can lead to nephroxicity due to oxalate crystal formation, which can cause acute kidney injury⁸.

Zinc

Excess zinc can cause a disruption in copper and iron metabolism and has been associated with kidney damage in high doses. Clear clinical data on normal supplementation effects is limited, so it should be used with caution.

Vitamin D

Vitamin D in high doses can lead to hypercalcemia and subsequent soft tissue and renal calcification. It is vital to monitor dosages to prevent such negative outcomes.

Vitamin B Complex

While individual B vitamins are generally safe with respect to kidney function, high doses of certain B vitamins (like B6) over extended periods can lead to toxicity potentially affecting renal function.

Magnesium Glycinate

Magnesium is filtered by the kidneys, and excess intake can result in hypermagnesemia, particularly in individuals with compromised renal function⁹.

Magnesium L-Threonate

Like other forms of magnesium, it can lead to toxicity in cases of renal impairment. Proper renal function is necessary for safe use.

Digestive Enzymes

Generally used for improving digestion, their impact on the kidneys is not well-documented, although GI disturbances may occur¹⁰.

Garlic Extract

High doses of garlic extract might lead to gastrointestinal irritation and, in very rare cases, may interact with medications affecting renal function.

Ginkgo Biloba

Ginkgo biloba is generally safe but can interact with several medications, inclusively impacting renal function indirectly.

L-Citrulline

It is metabolized by the kidneys and supports vascular health through NO production. Elevated levels can indicate renal insufficiency, but generally, citrulline supports kidney function by reducing inflammation¹¹.

Beta Alanine

Excessive supplementation of amino acids like beta alanine could lead to electrolyte imbalances and over time, may affect renal function indirectly¹².

Careful consideration and consultation with a healthcare provider are advisable before starting any supplement, especially if there is a pre-existing kidney condition.

Footnotes

1. Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali). ↩

2. Safety of Eurycoma longifolia (Tongkat Ali). ↩

3. Ashwagandha-induced liver injury—a case series from India. ↩

4. Ashwagandha-induced liver injury—a case series from India. ↩

5. Exploring scientifically proven herbal aphrodisiacs. ↩

6. Review of cases of patient risk associated with ginseng abuse and misuse. ↩ ↩²

7. L-Carnitine and its dietary factors. ↩ ↩²

8. Megadose Vitamin C Prescription Through Alternative Medicine Leading to End-Stage Renal Disease. ↩

9. Magnesium - StatPearls. ↩

10. Digestive Enzyme Supplementation in Gastrointestinal Diseases. ↩

11. L-Citrulline Supplementation and Exercise in the Management of Sarcopenia. ↩

12. Side Effects of Amino Acid Supplements. ↩