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Understanding Increased Sensitivity to Sleep Supplements and Drowsiness

Explore the potential causes of heightened sensitivity to supplements like magnesium, Theanine, THC, and melatonin, leading to prolonged grogginess. Consider factors such as metabolism changes, supplement interactions, medication interplay, and individual variations, and seek medical advice.

  • Supplement drowsiness

    In the evenings my brain won’t switch off to sleep but I can’t seem to take anything to sleep without having major grogginess the next day anymore.

    I used to be able to take supplements fine, ease into sleep, wake up refreshed. Now anything remotely sedating knocks me out almost immediately and keeps me groggy for 18 hours.

    I’m talking things like magnesium glycinate, Theanine, thc, melatonin etc I’ve played around with doses but nothing seems to help.

    What is going on with my body? Why is it so easily sedated ?

  • The increased sensitivity to supplements causing drowsiness that you're experiencing could be influenced by several factors:

    1. Changes in Metabolism: As we age or due to changes in diet, lifestyle, or health status, our bodies may metabolize supplements differently. This can lead to increased sensitivity to certain substances, resulting in more pronounced effects like drowsiness1.

    2. Supplement Interactions: You mentioned using magnesium glycinate, Theanine, THC, and melatonin. All of these can have sedative effects, and their use in combination might contribute to your symptoms of prolonged grogginess. For example, melatonin is generally safe but can cause daytime drowsiness in some people12.

    3. Interaction with Medications: If you are taking other medications, these supplements might interact with them, enhancing their sedative effects. Melatonin, for instance, can interact with medications that slow blood clotting, manage high blood pressure, or suppress the immune system2.

    4. Individual Variation: Your body might respond differently to these substances over time due to changes in your health status, hormonal levels, or medication use. Individual variations in receptor sensitivities can also play a role3.

    Given these possible factors, it would be beneficial to discuss your symptoms with a healthcare provider. They can assess your overall health, evaluate potential interactions, and possibly suggest alternative approaches or dosages tailored to your current sensitivity.

    Footnotes

    1. Mayo Clinic Staff, "Can a supplement help you sleep?," Mayo Clinic News Network, 2023. ↩ ↩2

    2. Brent A. Bauer, M.D., "Pros and cons of melatonin," Mayo Clinic, 2022. ↩ ↩2

    3. MedlinePlus, "5-HTP: MedlinePlus Supplements," MedlinePlus. ↩

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