There are several supplements known to help suppress appetite, some of which have shown varying degrees of effectiveness in clinical studies:

1. Phentermine and Topiramate: These medications are used to help adults and children aged 12 years or older who are obese, or certain adults who are overweight and have weight-related medical problems, to lose weight. Phentermine is an anorectic that decreases appetite, while Topiramate, originally used for epilepsy, also decreases appetite and prolongs feelings of fullness after eating¹².

2. Garcinia Cambogia: The active compound in this fruit-bearing tree, hydroxy citric acid (HCA), is thought to decrease fatty acid synthesis and lipogenesis, suppress appetite by increasing serotonin availability in the brain, and increase hepatic glycogen synthesis, thus increasing satiety. However, the clinical significance of its effect on weight loss is debatable, and safety concerns have been raised due to reports of liver toxicity³.

3. Berberine: This natural plant product has shown potential in reducing food intake, body weight, fat content, serum leptin, and glucose levels in experimental models. It appears to control appetite and improve lipid dysregulation by interacting with central obesity-related pathways⁴.

If you would like to search for specific products containing any of these ingredients, please let me know!

Footnotes

1. MedlinePlus Phentermine and Topiramate ↩

2. MedlinePlus Phentermine and Topiramate Page 2 ↩

3. Obesity Supplements - StatPearls - NCBI Bookshelf ↩

4. Berberine for Appetite Suppressant and Prevention of Obesity ↩