Yes, tryptophan supplements, particularly in the form of 5-hydroxytryptophan (5-HTP), have been shown to be effective in reducing appetite and promoting weight loss.

1. Appetite Regulation and Weight Loss: Studies indicate that 5-HTP supplementation can lead to reduced calorie intake and increased feelings of satiety or fullness. This effect has been particularly noted in people with overweight or obesity¹².

2. Clinical Studies: Clinical trials have demonstrated that 5-HTP can decrease carbohydrate and fat intake, thus supporting weight loss without the need for strict dietary restrictions³⁴. In one study, non-insulin dependent diabetic patients who took 5-HTP showed a significant reduction in their daily energy intake and body weight compared to those on a placebo³.

3. Long-term Effectiveness: Longer studies have confirmed these findings, suggesting that 5-HTP can help improve adherence to dietary prescriptions and consistently promote weight loss over extended periods¹⁴.

While these findings are promising, it's important to consult with a healthcare provider before starting any new supplement regimen, particularly for individuals with existing health conditions or those taking other medications.

Footnotes

1. Examine.com ↩ ↩²

2. PubMed ↩

3. NCBI ↩ ↩²

4. PubMed ↩ ↩²