Skip to main content
Evidence-Based Supplement Research
Evidence-Based Supplement Research
Pillser
Search
Sign UpLog In

A double-blind, randomized controlled trial to examine the effect of Moringa oleifera leaf powder supplementation on the immune status and anthropometric parameters of adult HIV patients on antiretroviral therapy in a resource-limited setting.

  • 2021-12-31
  • PloS one 16(12)
    • Aisha Gambo
    • Indres Moodley
    • Musa Babashani
    • Tesleem K Babalola
    • Nceba Gqaleni

Study Design

Type
Randomized Controlled Trial (RCT)
Population
200 HIV-positive adults on ART
Methods
Double-blind RCT, 200 HIV-positive patients randomized to Moringa oleifera leaf powder or placebo; CD4 and anthropometrics measured monthly for 6 months, viral load at baseline and end
Blinding
Double-blind
Duration
six months
Funding
Unclear

Background

People living with HIV (PLHIV) in resource-limited settings are vulnerable to malnutrition. Nutritional interventions aimed at improving food insecurity and malnutrition, together with antiretroviral therapy (ART), could improve treatment outcomes. In Nigeria, there is a high awareness of the nutraceutical benefits of Moringa oleifera. Thus, this study aimed to evaluate the effects of Moringa oleifera leaf supplementation on the CD4 counts, viral load and anthropometric of HIV-positive adults on ART.

Methods

This was a double-blind, randomized study. Two hundred HIV-positive patients were randomly allocated to either the Moringa Oleifera group (MOG) given Moringa oleifera leaf powder or the control group (COG) given a placebo. Changes in anthropometric parameters [weight; body mass index (BMI)] and CD4 cell counts were measured monthly for six months, while HIV-1 viral loads were measured at baseline and the end of the study for both groups.

Results

Over the study period, the treatment by time interaction shows a significant difference in CD4 counts by treatment group (p<0.0001). A further estimate of fixed effects showed that the CD4 counts among MOG were 10.33 folds greater than COG over the study period. However, the viral load (p = 0.9558) and all the anthropometric parameters (weight; p = 0.5556 and BMI; p = 0.5145) between the two groups were not significantly different over time. All tests were conducted at 95CI.

Conclusion

This study revealed that Moringa oleifera leaf supplementation was associated with increased CD4 cell counts of PLHIV on ART in a resource-limited setting. Programs in low-resource settings, such as Nigeria, should consider nutritional supplementation as part of a comprehensive approach to ensure optimal treatment outcomes in PLHIV.

Research Insights

  • Moringa→Increased CD4+ T Cell Count

    the treatment by time interaction shows a significant difference in CD4 counts by treatment group (p<0.0001). A further estimate of fixed effects showed that the CD4 counts among MOG were 10.33 folds greater than COG over the study period.

    Effect
    Beneficial
    Effect size
    Large
    Dose
    not specified
  • Moringa→Reduced Body Mass Index

    all the anthropometric parameters (weight; p = 0.5556 and BMI; p = 0.5145) between the two groups were not significantly different over time.

    Effect
    Neutral
    Effect size
    Small
    Dose
    not specified
  • Moringa→Reduced Body Weight

    all the anthropometric parameters (weight; p = 0.5556 ...) between the two groups were not significantly different over time.

    Effect
    Neutral
    Effect size
    Small
    Dose
    not specified
  • Moringa→Reduced Viral Load

    the viral load (p = 0.9558) ... between the two groups were not significantly different over time.

    Effect
    Neutral
    Effect size
    Small
    Dose
    not specified
Back to top