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A Pilot Study of the Effect of Lactobacillus casei Obtained from Long-Lived Elderly on Blood Biochemical, Oxidative, and Inflammatory Markers, and on Gut Microbiota in Young Volunteers

  • 2021-10-29
  • Nutrients 13(11)
    • Lijun Mei
    • Wenlong Zheng
    • Zheng-Tao Zhao
    • N. Meng
    • Qin-Ren Zhang
    • Wenyang Zhu
    • Rui-Ding Li
    • Xiao-Lin Liang
    • Quanyang Li

Abstract

Probiotic intake has been shown to improve certain physiological health indicators. We aimed to examine effects of Lactobacillus casei LTL1879, obtained from long-lived elderly volunteers, on blood biochemical, oxidative, and inflammatory markers and gut microbiota in twenty healthy, young volunteers. Volunteers were randomly divided into equal probiotic and placebo groups and changes in blood biochemical indicators, oxidative and inflammatory markers, and gut microbiota were examined after three weeks of probiotic intervention. The probiotic group's antioxidant levels were significantly enhanced post-intervention. Total antioxidant capacity (T-AOC) levels were significantly increased (p < 0.0001), while malondialdehyde (MDA) levels decreased (p < 0.05), and total superoxide dismutase (T-SOD) levels increased, but with no significant difference. In addition, Interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α) levels were significantly up-regulated and down-regulated (p < 0.05, respectively). Escherichia coli, Enterococcus, and Bacteroides expression was significantly reduced (p < 0.05), while Clostridium leptum, Bifidobacterium, and Lactobacillus expression increased (p < 0.05). Volunteer health status was quantified using principal components and cluster analysis, indicating that the probiotic group's overall score was higher than that of the placebo group. The results of this pilot study suggest L. casei LTL 1879 can significantly improve specific immune, oxidative, and gut microbiota characteristics related to health factors.

Keywords: Lactobacillus casei LTL1879; blood biochemical; gut microbiota; healthy young people; inflammation; oxidant; probiotics.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus caseiAltered Gut Microbiota CompositionBeneficial
Large
Lactobacillus caseiImproved Antioxidant LevelsBeneficial
Large
Lactobacillus caseiImproved Overall Health StatusBeneficial
Moderate
Lactobacillus caseiRegulated InflammationBeneficial
Moderate
Lactobacillus casei HA-108Elevated Antioxidant LevelsBeneficial
Large
Lactobacillus casei HA-108Increased Interleukin-10 LevelsBeneficial
Small
Lactobacillus casei HA-108Increased Superoxide Dismutase ActivityBeneficial
Small
Lactobacillus casei HA-108Reduced Serum Malondialdehyde LevelsBeneficial
Small
Lactobacillus casei HA-108Reduced TNF-α LevelsBeneficial
Small
Lactobacillus casei R0215Elevated Interleukin-10 LevelsBeneficial
Small
Lactobacillus casei R0215Improved Health Status ScoreBeneficial
Moderate
Lactobacillus casei R0215Improved Total Antioxidant CapacityBeneficial
Large
Lactobacillus casei R0215Increased Bifidobacterium LevelsBeneficial
Small
Lactobacillus casei R0215Increased Clostridium leptum ExpressionBeneficial
Small
Lactobacillus casei R0215Increased Superoxide Dismutase ActivityBeneficial
Small
Lactobacillus casei R0215Reduced Bacteroides ExpressionBeneficial
Small
Lactobacillus casei R0215Reduced Enterococcus ExpressionBeneficial
Small
Lactobacillus casei R0215Reduced Escherichia coli ExpressionBeneficial
Small
Lactobacillus casei R0215Reduced Serum Malondialdehyde LevelsBeneficial
Small
Lactobacillus casei R0215Reduced Tumor Necrosis Factor AlphaBeneficial
Small
Lactobacillus casei subsp. caseiElevated Interleukin-10 LevelsBeneficial
Small
Lactobacillus casei subsp. caseiImproved Antioxidant CapacityBeneficial
Large
Lactobacillus casei subsp. caseiImproved Overall Health StatusBeneficial
Moderate
Lactobacillus casei subsp. caseiIncreased Superoxide Dismutase ActivityBeneficial
Small
Lactobacillus casei subsp. caseiReduced Serum Malondialdehyde LevelsBeneficial
Small
Lactobacillus casei subsp. caseiReduced TNF-α LevelsBeneficial
Small
Lactobacillus casei UALc-03Elevated Antioxidant LevelsBeneficial
Large
Lactobacillus casei UALc-03Improved Gut Microbiome CompositionBeneficial
Moderate
Lactobacillus casei UALc-03Improved Overall Health StatusBeneficial
Moderate
Lactobacillus casei UALc-03Increased Anti-Inflammatory Marker LevelsBeneficial
Moderate
Lactobacillus casei VK4Elevated Antioxidant LevelsBeneficial
Large
Lactobacillus casei VK4Improved Inflammatory ResponseBeneficial
Moderate
Lactobacillus casei VK4Improved Overall Health StatusBeneficial
Moderate
Lactobacillus casei VK4Reduced Hepatic Oxidative StressBeneficial
Moderate
Lactobacillus sakei proBio65Elevated Antioxidant LevelsBeneficial
Large
Lactobacillus sakei proBio65Improved Gut Microbiota ProfileBeneficial
Moderate
Lactobacillus sakei proBio65Improved Inflammatory BiomarkersBeneficial
Moderate
Lactobacillus sakei proBio65Improved Overall Health StatusBeneficial
Moderate

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