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Antidiabetic (type 2) effects of Lactobacillus G15 and Q14 in rats through regulation of intestinal permeability and microbiota.

  • 2016
  • Food & Function 7(9)
    • Peijun Tian
    • Baolong Li
    • Canxia He
    • Wei Song
    • Aiju Hou
    • Sicong Tian
    • Xinyu Meng
    • Kaikai Li
    • Yujuan Shan

Abstract

The antidiabetic effects of Lactobacillus. paracasei subsp. paracasei G15 and Lactobacillus. casei Q14 in high fat diet and streptozotocin-induced type 2 diabetic (T2D) rats were evaluated in this study. The strains were separated from Chinese traditional fermented dairy food. Administration of G15 and Q14 for 6 weeks significantly improved the glucose tolerance and reduced the HbA1c levels in T2D rats. The probiotic treatment reduced the intestinal mucosal permeability and improved the epithelial barrier function through modification of the gut microbiota, which in turn lowered circulating LPS and inflammation cytokines, including IL-1β and IL-8, and eventually alleviated the inflammatory status and islet β-cell dysfunction. Combination of Q14 and metformin reversed the thymic atrophy and both G15 and Q14 lowered the circulating IL-6 level, indicating the immune-modulating potential of the strains. Lactobacillus. paracasei subsp. paracasei G15 and Lactobacillus. casei Q14 provide an insight into the biotherapy application of traditional fermented foods and their functional ingredients in the treatment of diabetes.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus casei subsp. caseiImproved Epithelial Barrier FunctionBeneficial
Moderate
Lactobacillus casei subsp. caseiImproved Glucose ToleranceBeneficial
Large
Lactobacillus casei subsp. caseiReduced Blood HbA1c LevelsBeneficial
Large
Lactobacillus casei subsp. caseiReduced IL-6 LevelsBeneficial
Moderate
Lactobacillus paracasei DSM 13434Improved Glucose ToleranceBeneficial
Large
Lactobacillus paracasei DSM 13434Reduced Blood HbA1c LevelsBeneficial
Large
Lactobacillus paracasei DSM 13434Reduced IL-6 LevelsBeneficial
Moderate
Lactobacillus paracasei DSM 13434Reduced Intestinal PermeabilityBeneficial
Moderate
Lactobacillus paracasei DSM 13434Reversed Thymic AtrophyBeneficial
Moderate
Lactobacillus paracasei IMC 502Enhanced Immune FunctionBeneficial
Moderate
Lactobacillus paracasei IMC 502Improved Glucose ToleranceBeneficial
Large
Lactobacillus paracasei IMC 502Improved Intestinal Barrier FunctionBeneficial
Moderate
Lactobacillus paracasei IMC 502Reduced Blood HbA1c LevelsBeneficial
Large
Lactobacillus paracasei IMC 502Reduced Inflammation LevelsBeneficial
Moderate
Lactobacillus paracasei LPC09Improved Epithelial Barrier FunctionBeneficial
Moderate
Lactobacillus paracasei LPC09Improved Glucose ToleranceBeneficial
Large
Lactobacillus paracasei LPC09Reduced Blood HbA1c LevelsBeneficial
Large
Lactobacillus paracasei LPC09Reduced IL-6 LevelsBeneficial
Moderate
Lactobacillus paracasei LPC09Reduced Inflammatory Cytokine LevelsBeneficial
Large
Lactobacillus paracasei LPC09Reduced Intestinal PermeabilityBeneficial
Moderate
Lactobacillus paracasei LPC09Reduced Islet β-Cell DysfunctionBeneficial
Moderate
Lactobacillus paracasei subsp. paracasei UALs-04Improved Glucose ToleranceBeneficial
Large
Lactobacillus paracasei subsp. paracasei UALs-04Improved ImmunomodulationBeneficial
Moderate
Lactobacillus paracasei subsp. paracasei UALs-04Reduced Blood HbA1c LevelsBeneficial
Large
Lactobacillus paracasei subsp. paracasei UALs-04Reduced IL-6 LevelsBeneficial
Moderate
Lactobacillus paracasei subsp. paracasei UALs-04Reduced Intestinal PermeabilityBeneficial
Moderate
Lactobacillus paracasei subsp. paracasei UALs-04Reversed Thymic AtrophyBeneficial
Moderate

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