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Association between riboflavin intake and the risk of all-cause mortality of patients with chronic kidney disease: A retrospective cohort study.

  • 2024-09-27
  • Medicine 103(39)
    • Xiaoxu Ren
    • Rong Wang
    • Fen Liu
    • Quanzhen Wang
    • Hairong Chen
    • Yunfeng Hou
    • Lifeng Yu
    • Xiangchun Liu
    • Zhiming Jiang

Study Design

Type
Observational
Sample size
n = 3,750
Population
3750 patients with chronic kidney disease (CKD)
Methods
retrospective cohort study with data extracted from the National Health and Nutrition Examination Survey (NHANES), Cox regression analysis
Funding
Unclear
Current studies have not clarified the relationship between riboflavin intake and all-cause mortality in patients with chronic kidney disease (CKD). The aim of this study is to investigate whether there is an association between riboflavin intake and the risk of all-cause mortality in patients with CKD. This was a retrospective cohort study with data extracted from the National Health and Nutrition Examination Survey (NHANES). The study was conducted using Cox regression analysis to calculate hazard ratio (HR) and 95% confidence interval (CI) to assess the association between riboflavin intake and risk of all-cause mortality. Subgroup analyses were performed regarding gender, CKD stage, hypertension, hyperlipidemia and cardiovascular disease (CVD). A total of 3750 patients were ultimately included in the analyses. After excluding potential confounders, lower intake of riboflavin was associated with the higher risk of all-cause mortality (Q1: HR = 1.33, 95% CI: 1.05-1.69). The similar association was also found in patients at mild/moderate stage (HR = 1.32, 95% CI: 1.05-1.66), in female (HR = 1.35, 95% CI: 1.01-1.81), with hypertension (HR = 1.37, 95% CI: 1.07-1.75), CVD (HR = 1.48, 95% CI: 1.08-2.03), and dyslipidemia (HR = 1.29, 95% CI: 1.01-1.66). This study found the association between low riboflavin intake and high risk of all-cause mortality, indicating a potential beneficial role of riboflavin in CKD patients.

Research Insights

  • Vitamin B2→Reduced All-Cause Mortality

    Lower intake of riboflavin was associated with the higher risk of all-cause mortality (Q1: HR = 1.33, 95% CI: 1.05-1.69).

    Effect
    Beneficial
    Effect size
    Moderate
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