Barberry (Berberis vulgaris L.) is a safe approach for management of lipid parameters: A systematic review and meta-analysis of randomized controlled trials.

2019-04
Complementary therapies in medicine 43
- Amir Hadi
- Arman Arab
- Ehsan Ghaedi
- Nahid Rafie
- Maryam Miraghajani
- Marzieh Kafeshani

PubMed: 30935518
DOI: 10.1016/j.ctim.2019.01.017

Study Design

Type: Meta-Analysis
Sample size: n = 339
Population: adult population
Methods: Meta-analysis; search included PubMed, Scopus, ISI Web of Science, Cochrane library, and Google Scholar (up to October 2018) to identify RCTs investigating the effects of barberry supplementation on serum lipid parameters; Mean Difference pooled using a random-effects model

Objective

We performed a meta-analysis to evaluate the efficacy of barberry supplementation on plasma lipid concentration in adult population.

Methods

The search included PubMed, Scopus, ISI Web of Science, Cochrane library, and Google Scholar (up to October 2018) to identify randomized controlled trials (RCTs) investigating the effects of barberry supplementation on serum lipid parameters. Mean Difference (MD) was pooled using a random-effects model.

Results

Meta-analysis on 5 RCTs with 339 participants indicated that barberry supplementation significantly decreased the levels of total cholesterol (MD: -23.58 mg/dl, 95% CI: -31.00 to -16.16, P ≤ 0.001), triglyceride (MD: -29.16 mg/dl, 95% CI: -42.91 to -15.41, P ≤ 0.001), and low-density lipoprotein cholesterol (MD: -13.75 mg/dl, 95% CI: -19.31 to -8.20, P ≤ 0.001) whereas changes in high-density lipoprotein cholesterol (MD: 3.40 mg/dl, 95% CI: -0.06-6.87, P = 0.054) was not statistically significant.

Conclusion

This systematic review and meta-analysis suggested the efficacy of barberry supplementation on lipid parameters. However, further large-scale studies are needed to confirm these results.