Beneficial insights into postbiotics against colorectal cancer.
- 2023-03-10
- Frontiers in nutrition 10
- Dingka Song
- Xiuli Wang
- Yongjing Ma
- Ning-Ning Liu
- Hui Wang
- PubMed: 36969804
- DOI: 10.3389/fnut.2023.1111872
Colorectal cancer (CRC) is one of the most prevalent and life-threatening cancer types with limited therapeutic options worldwide. Gut microbiota has been recognized as the pivotal determinant in maintaining gastrointestinal (GI) tract homeostasis, while dysbiosis of gut microbiota contributes to CRC development. Recently, the beneficial role of postbiotics, a new concept in describing microorganism derived substances, in CRC has been uncovered by various studies. However, a comprehensive characterization of the molecular identity, mechanism of action, or routes of administration of postbiotics, particularly their role in CRC, is still lacking. In this review, we outline the current state of research toward the beneficial effects of gut microbiota derived postbiotics against CRC, which will represent the key elements of future precision-medicine approaches in the development of novel therapeutic strategies targeting gut microbiota to improve treatment outcomes in CRC.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus brevis SBC8803 | Reduced Colorectal Cancer Cell Proliferation | Beneficial | Small |
| Saccharomyces cerevisiae fermentate | Reduced Colorectal Cancer Cell Proliferation | Beneficial | Small |
| Saccharomyces cerevisiae fermentate | Reduced Risk of Colorectal Cancer | Beneficial | Small |