Skip to main content

Abstract

Antibiotic-associated diarrhea (AAD) is a common side effect during antibiotic treatment. In this study, we evaluated the regulatory effect of Bifidobacterium animalis subsp_. lactis_ XLTG11 on mouse diarrhea caused by antibiotic-induced intestinal flora disturbance. Then, two strains of Bifidobacterium animalis subsp_. lactis_ XLTG11 and Bifidobacterium animalis subsp_. lactis_ BB-12 were administered to AAD mice. We found that the recovery effect of using B. lactis XLTG11 was better than that of B. lactis BB-12. B. lactis XLTG11 reduced the pathological characteristics of the intestinal tract, and significantly reduced the levels of lipopolysaccharide (LPS), D-lactic acid (D-LA) and diamine oxidase (DAO) to decrease intestinal permeability. In addition, these two strains significantly increased the expression of aquaporin and tight junction proteins, and inhibited toll-like receptor 4 (TLR4)/activation of the nuclear factor-κB (NF-κB) signaling pathway, significantly increased the levels of anti-inflammatory cytokines and decreased levels of pro-inflammatory cytokines. Moreover, after treatment with B. lactis XLTG11, the contents of acetic acid, propionic acid, butyric acid and total short-chain fatty acids were significantly increased. Compared with the MC group, B. lactis XLTG11 increased the abundance and diversity of the intestinal flora and changed the composition of the intestinal flora. We found that B. lactis XLTG11 can promote the recovery of intestinal flora and mucosal barrier function, thereby effectively improving AAD-related symptoms, providing a scientific basis for future clinical applications.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium animalisImproved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium animalisReduced Inflammation LevelsBeneficial
Large
Bifidobacterium animalisReduced Intestinal PermeabilityBeneficial
Moderate
Bifidobacterium animalis subsp. lactisImproved Gut Microbiota DiversityBeneficial
Large
Bifidobacterium animalis subsp. lactisImproved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium animalis subsp. lactisReduced Antibiotic-Associated DiarrheaBeneficial
Moderate
Bifidobacterium animalis subsp. lactisReduced Inflammation LevelsBeneficial
Large
Bifidobacterium animalis subsp. lactis B420Enhanced Anti-inflammatory ResponseBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Improved Gut Microbiome CompositionBeneficial
Large
Bifidobacterium animalis subsp. lactis B420Improved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium animalis subsp. lactis VK2Increased Short-Chain Fatty Acid LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis VK2Inhibited TLR4 SignalingBeneficial
Moderate
Bifidobacterium animalis subsp. lactis VK2Reduced Antibiotic-Associated Diarrhea SymptomsBeneficial
Large
Bifidobacterium animalis subsp. lactis VK2Reduced Intestinal PermeabilityBeneficial
Moderate
Bifidobacterium animalis subsp. lactis VK2Relieved Intestinal ImpairmentsBeneficial
Moderate
Bifidobacterium bifidum/lactis Bb-02Improved Tight Junction Protein ExpressionBeneficial
Moderate
Bifidobacterium bifidum/lactis Bb-02Increased Anti-Inflammatory Cytokine LevelsBeneficial
Moderate
Bifidobacterium bifidum/lactis Bb-02Increased Short-Chain Fatty Acid LevelsBeneficial
Moderate
Bifidobacterium bifidum/lactis Bb-02Inhibited TLR4 SignalingBeneficial
Moderate
Bifidobacterium bifidum/lactis Bb-02Reduced Antibiotic-Associated DiarrheaBeneficial
Moderate
Bifidobacterium bifidum/lactis Bb-02Reduced Intestinal PermeabilityBeneficial
Moderate
Bifidobacterium bifidum/lactis Bb-02Reduced Pro-Inflammatory CytokinesBeneficial
Moderate
Bifidobacterium lactisImproved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium lactisIncreased Short-Chain Fatty Acid LevelsBeneficial
Moderate
Bifidobacterium lactisReduced Antibiotic-Associated Diarrhea SymptomsBeneficial
Large
Bifidobacterium lactisReduced Intestinal InflammationBeneficial
Large
Bifidobacterium lactisReduced Intestinal PermeabilityBeneficial
Moderate
Bifidobacterium lactis BB-12Increased Anti-Inflammatory Cytokine LevelsBeneficial
Moderate
Bifidobacterium lactis BB-12Reduced Intestinal PermeabilityBeneficial
Moderate
Bifidobacterium lactis BB-12Reduced Pro-inflammatory Cytokines LevelsBeneficial
Moderate
Bifidobacterium lactis BI-04Improved Gut Flora DiversityBeneficial
Large
Bifidobacterium lactis BI-04Improved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium lactis BI-04Improved Production of Short-Chain Fatty AcidsBeneficial
Moderate
Bifidobacterium lactis BI-04Reduced Inflammation LevelsBeneficial
Large
Bifidobacterium lactis BI-04Reduced Intestinal PermeabilityBeneficial
Moderate
Bifidobacterium lactis Bl-04Improved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium lactis Bl-04Improved Intestinal Flora DiversityBeneficial
Large
Bifidobacterium lactis Bl-04Increased Short-Chain Fatty Acid ProductionBeneficial
Moderate
Bifidobacterium lactis Bl-04Reduced Inflammation LevelsBeneficial
Large
Bifidobacterium lactis BL818Improved AAD-Related SymptomsBeneficial
Large
Bifidobacterium lactis BL818Improved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium lactis BL818Increased Short-Chain Fatty Acid ProductionBeneficial
Moderate
Bifidobacterium lactis BL818Reduced Inflammatory ResponseBeneficial
Large
Bifidobacterium lactis BL818Reduced Intestinal PermeabilityBeneficial
Moderate
Bifidobacterium lactis BLA80Enhanced SCFA ProductionBeneficial
Moderate
Bifidobacterium lactis BLA80Improved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium lactis BLA80Improved Intestinal Flora DiversityBeneficial
Large
Bifidobacterium lactis BLA80Reduced Inflammation LevelsBeneficial
Large
Bifidobacterium lactis BLA80Reduced Intestinal PermeabilityBeneficial
Moderate
Bifidobacterium lactis BS01Improved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium lactis BS01Improved Production of Short-Chain Fatty AcidsBeneficial
Moderate
Bifidobacterium lactis BS01Reduced InflammationBeneficial
Large
Bifidobacterium lactis HDS Bb-02Improved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium lactis HDS Bb-02Improved Intestinal FloraBeneficial
Large
Bifidobacterium lactis HDS Bb-02Reduced Antibiotic-Associated DiarrheaBeneficial
Moderate
Bifidobacterium lactis ISS BifImproved Recovery from Antibiotic-Associated DiarrheaBeneficial
Large
Bifidobacterium lactis ISS BifIncreased Anti-Inflammatory Cytokine LevelsBeneficial
Moderate
Bifidobacterium lactis ISS BifIncreased Barrier-Preserving Protein LevelsBeneficial
Large
Bifidobacterium lactis ISS BifIncreased Short-Chain Fatty Acid LevelsBeneficial
Moderate
Bifidobacterium lactis ISS BifInhibited TLR4 SignalingBeneficial
Moderate
Bifidobacterium lactis ISS BifReduced Intestinal PermeabilityBeneficial
Moderate
Bifidobacterium lactis ISS BifReduced Pro-inflammatory Cytokines LevelsBeneficial
Moderate
Bifidobacterium lactis/longumImproved Intestinal Flora DiversityBeneficial
Large
Bifidobacterium lactis/longumIncreased Short-Chain Fatty Acid LevelsBeneficial
Moderate
Bifidobacterium lactis/longumReduced Inflammatory PathwaysBeneficial
Moderate
Bifidobacterium lactis/longumReduced Intestinal PermeabilityBeneficial
Moderate
Bifidobacterium lactis MAK16B42LImproved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium lactis MAK16B42LImproved Recovery of Intestinal FloraBeneficial
Large
Bifidobacterium lactis MAK16B42LIncreased Short-Chain Fatty Acid LevelsBeneficial
Moderate
Bifidobacterium lactis MAK16B42LReduced Antibiotic-Associated DiarrheaBeneficial
Moderate
Bifidobacterium lactis MAK16B42LReduced Inflammation LevelsBeneficial
Large
Bifidobacterium lactis MAK16B42LReduced Intestinal PermeabilityBeneficial
Moderate
Bifidobacterium lactis R101-8Improved Gut Microbiota DiversityBeneficial
Large
Bifidobacterium lactis R101-8Improved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium lactis R101-8Increased Short-Chain Fatty Acid LevelsBeneficial
Moderate
Bifidobacterium lactis R101-8Reduced Antibiotic-Associated DiarrheaBeneficial
Moderate
Bifidobacterium lactis R101-8Reduced Inflammation LevelsBeneficial
Large
Bifidobacterium lactis R101-8Reduced Intestinal PathologyBeneficial
Large
Bifidobacterium lactis SD-5219Improved Antibiotic-Associated DiarrheaBeneficial
Large
Bifidobacterium lactis SD-5219Improved Diversity of Intestinal FloraBeneficial
Large
Bifidobacterium lactis SD-5219Improved Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium lactis SD-5219Increased Short-Chain Fatty Acid LevelsBeneficial
Moderate
Bifidobacterium lactis SD-5219Reduced Intestinal InflammationBeneficial
Large

Pillser helps you make informed health decisions by providing comprehensive, unbiased information about supplements. This includes detailed research on supplement ingredients, their benefits, potential risks, and their overall efficacy. You can contribute by sharing your feedback and suggestions.

Send us an email at support@pillser.com.