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Bifidobacterium longum relieves constipation by regulating the intestinal barrier of mice.

  • 2022
  • Food & Function 13(9)
    • Linlin Wang
    • Mao-zhou Chai
    • Jialiang Wang
    • Q. Yu
    • G. Wang
    • H. Zhang
    • Jianxin Zhao
    • Wei Chen

Abstract

Constipation is a major health concern worldwide, requiring effective and safe treatment options. This study mainly focused on three species and nine strains of bifidobacteria from different sources to study their abilities to relieve constipation induced by loperamide in BALB/C mice. By monitoring constipation-related indicators, it was found that only Bifidobacterium longum (B. longum) relieved constipation, which indicated that bifidobacteria had inter-species differences in relieving constipation. Furthermore, through the detection of biological, chemical, mechanical, and immune barriers in mice, it was discovered that B. longum upregulates the relative abundance of 22 genera that were positively related to faecal water content, small intestinal propulsion rate, acetate, propionate, and intestinal mechanical barrier and negatively correlated with inflammatory factors, AQP8 and the time of first black stool and downregulates the relative abundance of Akkermansia. Furthermore, it increased the level of acetate in faeces and reduced the expression of AQP8 in the colon. This enhances intestinal motility and improves water and electrolyte metabolism. Meanwhile, it inhibited inflammation and prevented loperamide-induced intestinal barrier damage in constipated mice by upregulating occludin and downregulating IL-1β and TNF-α. In summary, B. longum relieved constipation by regulating the intestinal barrier in constipated mice.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium longum B1-05Improved Intestinal MotilityBeneficial
Moderate
Bifidobacterium longum B1-05Prevention of Intestinal Barrier DamageBeneficial
Moderate
Bifidobacterium longum B1-05Reduced InflammationBeneficial
Moderate
Bifidobacterium longum B1-05Relieved ConstipationBeneficial
Large
Bifidobacterium longum BI-05Improved Constipation ReliefBeneficial
Large
Bifidobacterium longum BI-05Improved Intestinal MotilityBeneficial
Moderate
Bifidobacterium longum BI-05Reduced Intestinal InflammationBeneficial
Moderate
Bifidobacterium longum BL03Improved Intestinal MotilityBeneficial
Moderate
Bifidobacterium longum BL03Prevention of Intestinal Barrier DamageBeneficial
Moderate
Bifidobacterium longum BL03Reduced Inflammation LevelsBeneficial
Moderate
Bifidobacterium longum BL03Relieved ConstipationBeneficial
Large
Bifidobacterium longum HA-135Improved Intestinal MotilityBeneficial
Moderate
Bifidobacterium longum HA-135Prevention of Intestinal Barrier DamageBeneficial
Moderate
Bifidobacterium longum HA-135Reduced Inflammation LevelsBeneficial
Moderate
Bifidobacterium longum HA-135Relieved ConstipationBeneficial
Large
Bifidobacterium longum KABP-042Improved Intestinal Barrier FunctionBeneficial
Moderate
Bifidobacterium longum KABP-042Improved Intestinal MotilityBeneficial
Moderate
Bifidobacterium longum KABP-042Reduced Intestinal InflammationBeneficial
Moderate
Bifidobacterium longum KABP-042Relieved ConstipationBeneficial
Large
Bifidobacterium longum MAK34B12LImproved Intestinal MotilityBeneficial
Moderate
Bifidobacterium longum MAK34B12LReduced Intestinal InflammationBeneficial
Moderate
Bifidobacterium longum MAK34B12LRegulated Intestinal Barrier FunctionBeneficial
Large
Bifidobacterium longum MM-2Improved Intestinal Barrier FunctionBeneficial
Moderate
Bifidobacterium longum MM-2Improved Intestinal MotilityBeneficial
Moderate
Bifidobacterium longum MM-2Reduced Inflammation LevelsBeneficial
Moderate
Bifidobacterium longum MM-2Relieved ConstipationBeneficial
Large
Bifidobacterium longum Rosell-175Improved Intestinal MotilityBeneficial
Moderate
Bifidobacterium longum Rosell-175Reduced Inflammation LevelsBeneficial
Moderate
Bifidobacterium longum SD-5588Improved Intestinal MotilityBeneficial
Moderate
Bifidobacterium longum SD-5588Prevention of Intestinal Barrier DamageBeneficial
Moderate
Bifidobacterium longum SD-5588Reduced Inflammation LevelsBeneficial
Moderate
Bifidobacterium longum SD-5588Relieved ConstipationBeneficial
Large
Bifidobacterium longum SP54Improved Intestinal Barrier FunctionBeneficial
Moderate
Bifidobacterium longum SP54Improved Intestinal MotilityBeneficial
Moderate
Bifidobacterium longum SP54Reduced Inflammation LevelsBeneficial
Moderate
Bifidobacterium longum SP54Relieved ConstipationBeneficial
Large
Bifidobacterium longum subsp. longumImproved Intestinal MotilityBeneficial
Moderate
Bifidobacterium longum subsp. longumIncreased Fecal Water ContentBeneficial
Moderate
Bifidobacterium longum subsp. longumPrevention of Intestinal Barrier DamageBeneficial
Moderate
Bifidobacterium longum subsp. longumReduced Inflammation LevelsBeneficial
Moderate
Bifidobacterium longum subsp. longumRelieved ConstipationBeneficial
Large
Bifidobacterium longum subsp. longum 35624Improved Intestinal MotilityBeneficial
Moderate
Bifidobacterium longum subsp. longum 35624Reduced InflammationBeneficial
Moderate
Bifidobacterium longum subsp. longum 35624Relieved ConstipationBeneficial
Large
Bifidobacterium longum subsp. longum UABI-14Improved Intestinal Barrier FunctionBeneficial
Moderate
Bifidobacterium longum subsp. longum UABI-14Improved Intestinal MotilityBeneficial
Moderate
Bifidobacterium longum subsp. longum UABI-14Reduced Colonic InflammationBeneficial
Large
Bifidobacterium longum UABI-14Improved Intestinal MotilityBeneficial
Moderate
Bifidobacterium longum UABI-14Reduced AQP8 Expression in ColonBeneficial
Moderate
Bifidobacterium longum UABI-14Reduced InflammationBeneficial
Moderate

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