Wei Chen

Jiangnan University

Health Outcomes Studied

• Improved Gut Microbiome
• Improved Gut Microbiota
• Improved Gut Microbiota Diversity
• Improved Insulin Sensitivity
• Increased Anti-Inflammatory Cytokine Levels
• Increased Butyrate Levels
• Increased Fecal Bile Acid Levels
• Increased Fecal Lactobacilli
• Increased Interleukin-10 Levels
• Increased Intestinal GLP-1 Levels
• Increased Regulatory T Cell Count
• Increased Serotonin Levels
• Increased Serum BDNF Levels
• Increased Short-Chain Fatty Acid Levels
• Reduced Body Weight
• Reduced Diarrhea Rate
• Reduced Obesity
• Reduced Total Cholesterol Levels

Papers (53)

• 2026
  Proteomic antibacterial characterization of flavonoid xanthohumol and probiotic Clostridium butyricum on pathogenic Clostridioides difficile.10.1186/s13020-026-01343-x
• 2026
  The unsaturated fatty acid of the cell membrane and the accumulation of intracellular glutamic acid as key determinants of freeze-drying tolerance in Bifidobacterium bifidum.10.1016/j.foodres.2026.118444
• 2026
  Bacteriocin gene-mediated ecological adaptation of Bifidobacterium breve in the adult human gut.10.1016/j.xgen.2025.101106
• 2026
  Autoinducer 2 as a universal language in microbial consortia: decoding molecular mechanisms, ecological impacts, and application.10.1080/19490976.2026.2615494
• 2023
  Integrative analysis of the metabolome and transcriptome reveals the influence of Lactobacillus plantarum CCFM8610 on germ-free mice.10.1039/d2fo03117e
• 2023
  Bifidobacterium longum subsp. infantis FJSYZ1M3 ameliorates DSS-induced colitis by maintaining the intestinal barrier, regulating inflammatory cytokines, and modifying gut microbiota.10.1039/d2fo03263e
• 2023
  Bifidobacterium animalis subsp. lactis boosts neonatal immunity: unravelling systemic defences against Salmonella.10.1039/d3fo03686c
• 2022
  Effects of Bacillus coagulans GBI-30, 6086 as an adjunct starter culture on the production of yogurt.10.1016/j.foodres.2022.111398
• 2022
  Lactiplantibacillus Plantarum CCFM8724 Reduces the Amounts of Oral Pathogens and Alters the Oral Microbiota in Children With Dental Caries: a Randomized, Double-Blind, Placebo-Controlled Trial.10.1080/07315724.2022.2043200
• 2022
  Bifidobacterium adolescentis Is Effective in Relieving Type 2 Diabetes and May Be Related to Its Dominant Core Genome and Gut Microbiota Modulation Capacity10.3390/nu14122479
• 2022
  Lactobacillus paracasei CCFM1229 and Lactobacillus rhamnosus CCFM1228 Alleviated Depression- and Anxiety-Related Symptoms of Chronic Stress-Induced Depression in Mice by Regulating Xanthine Oxidase Activity in the Brain10.3390/nu14061294
• 2022
  Different effects of Bacillus coagulans vegetative cells and spore isolates on constipation-induced gut microbiota dysbiosis in mice.10.1039/d2fo01668k
• 2022
  Bifidobacterium longum relieves constipation by regulating the intestinal barrier of mice.10.1039/d1fo04151g
• 2022
  Bifidobacterium breve CCFM1078 Alleviates Collagen-Induced Arthritis in Rats via Modulating the Gut Microbiota and Repairing the Intestinal Barrier Damage.10.1021/acs.jafc.2c04602
• 2021
  Identification of the key characteristics of Bifidobacterium longum strains for the alleviation of ulcerative colitis.10.1039/d1fo00017a
• 2021
  Daily intake of Lactobacillus alleviates autistic-like behaviors by ameliorating the 5-hydroxytryptamine metabolic disorder in VPA-treated rats during weaning and sexual maturation.10.1039/d0fo02375b
• 2021
  Bifidobacterium adolescentis Isolated from Different Hosts Modifies the Intestinal Microbiota and Displays Differential Metabolic and Immunomodulatory Properties in Mice Fed a High-Fat Diet10.3390/nu13031017
• 2021
  Effects of Bacillus coagulans as an adjunct starter culture on yogurt quality and storage.10.3168/jds.2020-19876
• 2021
  Lactobacillus rhamnosus FJSYC4-1 and Lactobacillus reuteri FGSZY33L6 alleviate metabolic syndrome via gut microbiota regulation.10.1039/d0fo02879g
• 2021
  Lactobacillus reuteri FYNLJ109L1 Attenuating Metabolic Syndrome in Mice via Gut Microbiota Modulation and Alleviating Inflammation10.3390/foods10092081
• 2021
  Different Bifidobacterium bifidum strains change the intestinal flora composition of mice via different mechanisms to alleviate loperamide-induced constipation.10.1039/d1fo00559f
• 2021
  Comparative Peptidomics Analysis of Fermented Milk by Lactobacillus delbrueckii ssp. bulgaricus and Lactobacillus delbrueckii ssp. lactis10.3390/foods10123028
• 2021
  Bifidobacterium bifidum Shows More Diversified Ways of Relieving Non-Alcoholic Fatty Liver Compared with Bifidobacterium adolescentis10.3390/biomedicines10010084
• 2021
  Administration of Bifidobacterium breve Improves the Brain Function of Aβ1-42-Treated Mice via the Modulation of the Gut Microbiome10.3390/nu13051602
• 2021
  Effects of the short-term administration of Pediococcus pentosaceus on physiological characteristics, inflammation, and intestinal microecology in mice.10.1039/d0fo02948c
• 2021
  An optimized culture medium to isolate Lactobacillus fermentum strains from the human intestinal tract.10.1039/d1fo00209k
• 2021
  Bifidobacterium longum Ameliorates Dextran Sulfate Sodium-Induced Colitis by Producing Conjugated Linoleic Acid, Protecting Intestinal Mechanical Barrier, Restoring Unbalanced Gut Microbiota, and Regulating the Toll-Like Receptor-4/Nuclear Factor-κB Signaling Pathway.10.1021/acs.jafc.1c06176
• 2020
  Protective effects of Bifidobacterium adolescentis on collagen-induced arthritis in rats depend on timing of administration.10.1039/d0fo00077a
• 2020
  Bifidobacterium adolescentis and Lactobacillus rhamnosus alleviate non-alcoholic fatty liver disease induced by a high-fat, high-cholesterol diet through modulation of different gut microbiota-dependent pathways.10.1039/c9fo02905b
• 2020
  Towards a psychobiotic therapy for depression: Bifidobacterium breve CCFM1025 reverses chronic stress-induced depressive symptoms and gut microbial abnormalities in mice10.1016/j.ynstr.2020.100216
• 2020
  Comparative Genomics of Pediococcus pentosaceus Isolated From Different Niches Reveals Genetic Diversity in Carbohydrate Metabolism and Immune System10.3389/fmicb.2020.00253
• 2020
  Comparative Genomics of Lactobacillus crispatus from the Gut and Vagina Reveals Genetic Diversity and Lifestyle Adaptation10.3390/genes11040360
• 2020
  Comparative analysis of Lactobacillus gasseri from Chinese subjects reveals a new species-level taxa10.1186/s12864-020-6527-y
• 2020
  Identification of the key physiological characteristics of Lactobacillus plantarum strains for ulcerative colitis alleviation.10.1039/c9fo02935d
• 2020
  Prophylactic effects of oral administration of Lactobacillus casei on house dust mite-induced asthma in mice.10.1039/d0fo01363c
• 2020
  Lactobacillus plantarum relieves diarrhea caused by enterotoxin-producing Escherichia coli through inflammation modulation and gut microbiota regulation.10.1039/d0fo02670k
• 2020
  Screening of Lactobacillus salivarius strains from the feces of Chinese populations and the evaluation of their effects against intestinal inflammation in mice.10.1039/c9fo02116g
• 2019
  Clostridium butyricum Strains Suppress Experimental Acute Pancreatitis by Maintaining Intestinal Homeostasis.10.1002/mnfr.201801419
• 2019
  Bifidobacteria adolescentis regulated immune responses and gut microbial composition to alleviate DNFB-induced atopic dermatitis in mice10.1007/s00394-019-02145-8
• 2019
  Lactobacillus plantarum CCFM8661 modulates bile acid enterohepatic circulation and increases lead excretion in mice.10.1039/c8fo02554a
• 2019
  Short communication: Lactose utilization of Streptococcus thermophilus and correlations with β-galactosidase and urease.10.3168/jds.2019-17009
• 2019
  In vitro and in vivo evaluation of Lactobacillus strains and comparative genomic analysis of Lactobacillus plantarum CGMCC12436 reveal candidates of colonise-related genes.10.1016/j.foodres.2018.10.064
• 2019
  Ingestion of Bifidobacterium longum subspecies infantis strain CCFM687 regulated emotional behavior and the central BDNF pathway in chronic stress-induced depressive mice through reshaping the gut microbiota.10.1039/c9fo01630a
• 2019
  A ropy exopolysaccharide producing strain Bifidobacterium longum subsp. longum YS108R alleviates DSS-induced colitis by maintenance of the mucosal barrier and gut microbiota modulation.10.1039/c9fo00014c
• 2018
  Bifidobacteria attenuate the development of metabolic disorders, with inter- and intra-species differences.10.1039/c8fo00100f
• 2018
  Strain-specific properties of Lactobacillus plantarum for prevention of Salmonella infection.10.1039/c8fo00365c
• 2017
  Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells10.3389/fimmu.2017.01345
• 2017
  Bifidobacterium adolescentis Exerts Strain-Specific Effects on Constipation Induced by Loperamide in BALB/c Mice10.3390/ijms18020318
• 2017
  Bifidobacteria exert species-specific effects on constipation in BALB/c mice.10.1039/c6fo01641c
• 2017
  Lactobacillus casei CCFM419 attenuates type 2 diabetes via a gut microbiota dependent mechanism.10.1039/c7fo00593h
• 2010
  Complete Genome Sequence of Streptococcus thermophilus Strain ND0310.1128/JB.01374-10
• 2010
  Complete Genome Sequence of Probiotic Bifidobacterium animalis subsp. lactis Strain V910.1128/JB.00369-10
• 2009
  Fermentation characteristics and transit tolerance of probiotic Lactobacillus casei Zhang in soymilk and bovine milk during storage.10.3168/jds.2008-1849