- 2024-03-07
- Scandinavian journal of trauma, resuscitation and emergency medicine 32(1)
- Jia-Xing Song
- Jian-Xiang Wu
- Hai Zhong
- Wei Chen
- Jian-Chun Zheng
Study Design
- Type
- Meta-Analysis
- Population
- patients with traumatic brain injury (TBI)
- Methods
- Systematic review and meta-analysis of RCTs; databases PubMed, Embase, Web of Science, Cochrane Library searched from January 2000 to November 2023
Objective
Tranexamic acid (TXA) demonstrates therapeutic efficacy in the management of traumatic brain injury (TBI). The objective of this systematic review and meta-analysis was to evaluate the safety and effectiveness of TXA in patients with TBI.Methods
The databases, namely PubMed, Embase, Web of Science, and Cochrane Library databases, were systematically searched to retrieve randomized controlled trials (RCTs) investigating the efficacy of TXA for TBI from January 2000 to November 2023.Results
The present meta-analysis incorporates ten RCTs. Compared to the placebo group, administration of TXA in patients with TBI resulted in a significant reduction in mortality (P = 0.05), hemorrhage growth (P = 0.03), and volume of hemorrhage growth (P = 0.003). However, no significant impact was observed on neurosurgery outcomes (P = 0.25), seizure occurrence (P = 0.78), or pulmonary embolism incidence (P = 0.52).Conclusion
The administration of TXA is significantly associated with reduced mortality and hemorrhage growth in patients suffering from TBI, while the need of neurosurgery, seizures, and incidence of pulmonary embolism remains comparable to that observed with placebo.